7-Hydroxy-3-(4'-Methoxyphenyl)-4H-Benzopyran-4-One
刺芒柄花素(Formononetin)
CAS: 485-72-3
化学式: C16H12O4
| 中文名 | 刺芒柄花素 |
| 英文名 | Formononetin |
| 别名 | 芒柄花素 剌芒柄花素 刺芒柄花素 7-羟基-4-甲氧异苯酮 7-羟基-4'-甲氧异黄酮 7-羟基-3-(4-甲氧基苯基)色酮 芒柄花素(刺芒柄花素,刺芒柄花黄素,芒柄花黄素,生原禅宁B) |
| 英文别名 | Flavosil Myconate NSC 93360 ForMonentin Formononetin ForMoononetin Red Clover Extract Formononetin (50 mg) ForMononetin (ForMononetol) 7-Hydroxy-4'-methoxyisoflavone red clover extract_formononetin 7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one 7-Hydroxy-3-(4'-Methoxyphenyl)-4H-Benzopyran-4-One |
| CAS | 485-72-3 |
| EINECS | 207-623-9 |
| 化学式 | C16H12O4 |
| 分子量 | 268.26 |
| InChI | InChI=1/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3 |
| InChIKey | HKQYGTCOTHHOMP-UHFFFAOYSA-N |
| 密度 | 1.1529 (rough estimate) |
| 熔点 | 256-260 °C |
| 沸点 | 331.43°C (rough estimate) |
| 闪点 | 183.4°C |
| 蒸汽压 | 0Pa at 25℃ |
| 溶解度 | 溶于DMSO (高达100毫克/毫升)。 |
| 折射率 | 1.4350 (estimate) |
| 酸度系数 | 6.99±0.20(Predicted) |
| 存储条件 | 2-8°C |
| 稳定性 | 从提供的购买之日起稳定2年。DMSO中的溶液可以在-20 ° 下储存长达1个月。 |
| 外观 | 粉末 |
| 颜色 | White to light beige |
| 最大波长(λmax) | ['300nm(EtOH)(lit.)'] |
| Merck | 14,4244 |
| BRN | 237979 |
| 物化性质 | 白色结晶粉末，溶于甲醇、乙醇、丙酮，来源于黄芪根茎，豆科植物红车轴草（TrifoliumPratenseL）的花序及带花枝叶,刺芒柄花（Ononis spinosa）全草提取而得。 |
| MDL号 | MFCD00016948 |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S37/39 - 戴适当的手套和护目镜或面具。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| RTECS | DJ3100114 |
| 海关编号 | 29329990 |
| 参考资料 展开查看 | 1. 陆晖 陆瑞勇.HPLC测定玉郎伞中芒柄花素的含量[J].中国民族民间医药 2013 22(18):25-26. 2. 刘洋, 张鑫, 石秀佳,等. 基于PBPK模型的在体单向肠灌流技术对苷元成分的适用性分析评价[J]. 中国中药杂志, 2019(17):3645-3652. 3. 勾玲, 唐珍, 苏春蓝,等. 牛大力黄酮类成分提取条件的优化[J]. 检验检疫学刊, 2020, 030(002):P.78-80. 4. 刘雪 石晓倩 吴晏杰 等. UPLC法同时测定新安名方脑络欣通中5个活性成分的含量[J]. 贵阳中医学院学报 2020年42卷4期 26-31页 ISTIC 2020. 5. 黎映琼 蔡庆群 苏志强 等. 不同产地黄芪根 茎 叶中4种异黄酮类成分的比较及其聚类分析[J]. 现代中药研究与实践 2020 v.34;No.173(02):69-73. 6. 尚兴朴,欧阳罗丹,肖苏萍,王继永,高永坚,袁春平,刘畅.黄芪饮片质量评价和分级标准探讨[J].中国现代中药,2020,22(05):772-779. 7. 刘杰 何钢 刘贤桂 等. 人工栽培鸡血藤中五种黄酮类物质含量测定[J]. 分子植物育种 2017 015(009):3832-3837. 8. 侯美如, 尹珺伊, 王岩,等. 黄芪发酵前后黄酮含量及指纹图谱比较研究[J]. 中国兽药杂志, 2018, v.52(05):52-58. 9. 李欣, 卓冰雨, 祁晓娟,等. 黄芪异黄酮含量与气候因子的灰色关联度和通径分析[J]. 中国中药杂志 2020年45卷14期, 3407-3413页, MEDLINE ISTIC PKU CSCD CA BP, 2020. 10. 余颖, 樊金玲, 程源斌,等. 甘草酸提取废液α-葡萄糖苷酶抑制剂的筛选与鉴定[J]. 食品科学, 2018, 39(13). 11. 勾玲,唐珍,苏春蓝,姚水莲,卢海啸.牛大力标准提取物制备工艺研究[J].海峡药学,2020,32(11):1-3. 12. 杨雨桐,张卿硕,符韵林,孙静.巴里黄檀心材色素成分及其稳定性和抗氧化性[J].林业科学,2021,57(03):126-134. 13. 孙秀蕊,魏桂杰,王宏雅,赵雯雯,张哲,张婷,魏锋,张玉杰.基于外观性状和内在成分的黄芪药材质量等级评价[J].中国中药杂志,2021,46(04):966-971. 14. 常冠华,薄颖异,崔洁,徐露露,赵梓邯,王文全,侯俊玲.基于UPLC-Q-Exactive Orbitrap-MS分析甘草地上部分主要化学成分[J].中国中药杂志,2021,46(06):1449-1459. 15. 徐艳阳,赵玉娟,高峰,王二雷,鲁海玲,李雪凤,姜雯雯,陈艳.高效液相色谱法分析中国人参不同部位中多酚类化合物[J].食品科学,2021,42(04):240-246. 16. 田文仓. 不同生长年限及采收期子洲黄芪鉴别特征及其质量、产量差异分析[D].北京中医药大学,2020. 17. 冯紫薇. 子洲黄芪饮片质量等级标准研究[D].北京中医药大学,2020. 18. 毛文点,庹玲玲,齐文续,苏睿智,邓常清,邹龙.黄芪-当归不同配伍对其6种主要有效成分溶出的影响[J].湖南中医药大学学报,2021,41(03):350-354. 19. Peng-Peng, L. I. U., et al. "Metabolomics analysis and rapid identification of changes in chemical ingredients in crude and processed Astragali Radix by UPLC-QTOF-MS combined with novel informatics UNIFI platform." Chinese journal of natural medicines 16.9 20. Wang, Qian, et al. "Identification and pharmacokinetics of multiple constituents in rat plasma after oral administration of Yinchenzhufu decoction." Journal of ethnopharmacology 153.3 (2014): 714-724.http://doi.org/10.1016/j.jep.2014.03.039 21. Wang, Lingdi, et al. "Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency." Evidence-Based Complementary and Alternative Medicine 2021 (2021).http://doi.org/10.1155/2021/6614302 22. Mi, Nan, et al. "Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: an integrated strategy based on UPLC-QTOF/MS combined with multivariate statistical analysis." Journal of pharmaceutical and biomedical analysis 164 (2019): 70-85 23. Yang, Zhenzhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).http://doi.org/10.1016/ 24. [IF=4.759] Yuping Zhang et al."On-line surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali."J Chromatogr A. 2013 Jun;1293:92 25. [IF=4.522] Wei Hu et al."In vitro and in vivo studies of antiosteosarcoma activities of formononetin."J Cell Physiol. 2019 Oct;234(10):17305-17313 26. [IF=4.411] Jing Zhou et al."Simultaneous Optimization for Ultrasound-Assisted Extraction and Antioxidant Activity of Flavonoids from Sophora flavescens Using Response Surface Methodology."Molecules. 2019 Jan;24(1):112 27. [IF=4.411] Liangliang Liu et al."Rapid Screening and Identification of BSA Bound Ligands from Radix astragali Using BSA Immobilized Magnetic Nanoparticles Coupled with HPLC-MS."Molecules. 2016 Nov;21(11):1471 28. [IF=3.935] Nan Mi et al."Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: An integrated strategy based on UPLC-QTOF/MS combined with multivariate statistical analysis."J Pharmaceut Biomed. 2019 Feb;164:70 29. [IF=3.935] Ziying Liu et al."Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma."J Pharmaceut Bio 30. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 31. [IF=3.361] Taofang Cheng et al."Hybrid multidimensional data acquisition and data processing strategy for comprehensive characterization of known, unknown and isomeric compounds from the compound Dan Zhi Tablet by UPLC-TWIMS-QTOFMS."Rsc Adv. 2019 Mar;9(16):8714-8727 32. [IF=3.208] Teng Li et al."Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway."Drug Des Dev Ther. 2018; 12: 3675–3684 33. [IF=2.705] Shu Yang et al."Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα."Biochem Bioph Res Co. 2019 May;512:770 34. [IF=8.579] Chuanrui Ma et al."Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice."Theranostics. 2020; 10(3): 1090–1106 35. [IF=5.81] Gu Junfei et al."Standardized Astragalus Mongholicus Bunge-Curcuma Aromatica Salisb. Extract Efficiently Suppresses Colon Cancer Progression Through Gut Microbiota Modification in CT26-Bearing Mice."Front Pharmacol. 2021 Aug;0:2278 36. [IF=4.879] Yang Liu et al."UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings."Biomolecules. 2020 Apr;10(4):504 37. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;: 38. [IF=4.759] Wenjie Wu et al."An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example."J Chromato 39. [IF=4.486] Xin Li et al."Formononetin, J1 and J2 have different effects on endothelial cells via EWSAT1‐TRAF6 and its downstream pathway."J Cell Mol Med. 2020 Jan;24(1):875-885 40. [IF=4.411] Mengyang Hou et al."Preparative Purification of Total Flavonoids from Sophora tonkinensis Gagnep. by Macroporous Resin Column Chromatography and Comparative Analysis of Flavonoid Profiles by HPLC-PAD."Molecules. 2019 Jan;24(17):3200 41. [IF=4.411] Liyu Luo et al."Integrated Phytochemical Analysis Based on UPLC-MS and Network Pharmacology Approaches to Explore the Quality Control Markers for the Quality Assessment of Trifolium pratense L.."Molecules. 2020 Jan;25(17):3787 42. [IF=4.225] Zhang Wei et al."Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP–Induced Injury in HSCs."Front Pharmacol. 2019 Aug;0:936 43. [IF=4.142] Hu Guizhou et al."An integrated strategy for the identification and screening of anti-allergy components from natural products based on calcium fluctuations and cell extraction coupled with HPLC–Q–TOF–MS."Anal Bioanal Chem. 2021 Oct;413(25):6253-6266 44. [IF=3.69] Qian Zhang et al."Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia."J Ethnopharmacol. 2020 Apr;252:112573 45. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 46. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 47. [IF=2.984] Chenkai Wang et al."Comparative transcriptome analysis of roots, stems, and leaves of Pueraria lobata (Willd.) Ohwi: identification of genes involved in isoflavonoid biosynthesis."Peerj. 2021 Feb;9:e10885 48. [IF=2.633] Ruoke Ma et al."Variation of Chemical Components in Sapwood, Transition Zone, and Heartwood of Dalbergia odorifera and Its Relationship with Heartwood Formation."Forests. 2021 May;12(5):577 49. [IF=2.629] Wang Lingdi et al."Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency."Evid-Based Compl Alt. 2021;2021:6614302 50. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826 51. [IF=3.645] Jingbin Chen et al.Screening for potential quality markers of Callerya nitida var. hirsutissima. Z.Wei based on components profile, pharmacokinetics, and anti-inflammatory study.Journal Of Separation Science.2021 Nov 02 52. 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7-Hydroxy-3-(4'-Methoxyphenyl)-4H-Benzopyran-4-One - 简介
刺芒柄花素是一种天然植物色素，其化学名为芸香素。它通常呈黄色至橙黄色的结晶粉末状。
制取刺芒柄花素的常见方法是从蔷薇科植物刺芒柄花（Rubia cordifolia）中提取。首先将植物材料研磨成粉末，然后使用合适的溶剂进行提取，再经过过滤、浓缩和结晶等步骤得到刺芒柄花素。
在制备和使用过程中应严格按照相关规定和安全操作进行，避免接触皮肤和吸入。在儿童接触之前，应将其保存在儿童无法触及的地方。
制取刺芒柄花素的常见方法是从蔷薇科植物刺芒柄花（Rubia cordifolia）中提取。首先将植物材料研磨成粉末，然后使用合适的溶剂进行提取，再经过过滤、浓缩和结晶等步骤得到刺芒柄花素。
在制备和使用过程中应严格按照相关规定和安全操作进行，避免接触皮肤和吸入。在儿童接触之前，应将其保存在儿童无法触及的地方。
最后更新：2024-04-09 20:52:54
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产品名: 芒柄花黄素 紫外分光标准品 去供应商网站查看 询盘CAS: 485-72-3
产地: 北京
包装: 20mg /瓶
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提供多种规格现货供应
产品名: 7-羟基-3-(4-甲氧基苯基)-4H-苯并吡喃-4-酮 询盘CAS: 485-72-3
产地: 上海
包装: 10g；25g；5g；100g；100mg；1mL*10mM(in DMSO)；200mg；25mg；50mg；10mg；1mL*10mM(inDMSO)；500mg；20mg；1mLx10mM(in
规格: 98%；99.38%
价格: 电话、微信、QQ、邮件
库存: 现货
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产品名: Formononetin 去供应商网站查看 询盘CAS: 485-72-3
产地: 美国
包装: 5 mg;10 mg;25 mg;50 mg;100 mg
规格: HY-N0183R
库存: 询盘
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产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98%
提供多种规格
产品名: 芒柄花黄素 紫外分光标准品 去供应商网站查看 询盘CAS: 485-72-3
产地: 北京
包装: 20mg /瓶
规格: SVF1055-20mg
价格: 电话、微信、QQ、邮件
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: 7-羟基-3-(4-甲氧基苯基)-4H-苯并吡喃-4-酮 询盘CAS: 485-72-3
产地: 上海
包装: 10g；25g；5g；100g；100mg；1mL*10mM(in DMSO)；200mg；25mg；50mg；10mg；1mL*10mM(inDMSO)；500mg；20mg；1mLx10mM(in
规格: 98%；99.38%
价格: 电话、微信、QQ、邮件
库存: 现货
电话: 400-968-2212
手机: 18916960931
电子邮件: 3623107365@qq.com
QQ: 3623107365
微信: 18916960931
产品描述: 7-羟基-3-(4-甲氧基苯基)-4H-苯并吡喃-4-酮，98%；99.38%，Amole/阿摩尔
提供多种规格现货供应
产品名: Formononetin 去供应商网站查看 询盘CAS: 485-72-3
产地: 美国
包装: 5 mg;10 mg;25 mg;50 mg;100 mg
规格: HY-N0183R
库存: 询盘
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98%
7-Hydroxy-3-(4'-Methoxyphenyl)-4H-Benzopyran-4-One的上游原料
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