HSDB 3453
黄曲霉素B1(Aflaloxin B1)
CAS: 1162-65-8
化学式: C17H12O6
| 中文名 | 黄曲霉素B1 |
| 英文名 | Aflaloxin B1 |
| 别名 | 黄曲霉素B1 黄曲霉毒素 B1 黄曲霉素 B1 溶液 黄曲霉素 B1 来源于黄曲霉 黄曲霉素B1溶液,100PPM 黄曲霉素B1溶液,1000PPM 黄曲霉毒素 B1(黄曲霉素B1) AFLATOXIN 黄曲霉毒素B1 |
| 英文别名 | AFB1 CCRIS 12 HSDB 3453 NSC 529592 BRN 1269174 Aflaloxin B1 Aflatoxin B1 )(1)benzopyran-1,11-dione (6ar-cis)-ahydro-4-methoxy AFLATOXIN B1 FROM ASPERGILLUS FLAVUS AFLATOXIN B(1) FROM ASPERGILLUS FLAVUS, VIAL WITH 10 MG 1-Cyclopentene-1-carboxylic acid, 2-(3a,8a-dihydro-4-hydroxy-6-methoxyfuro[2,3-b]benzofuran-5-yl)-5-oxo-, delta-lactone |
| CAS | 1162-65-8 |
| EINECS | 214-603-3 |
| 化学式 | C17H12O6 |
| 分子量 | 312.27 |
| InChI | InChI=1/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1 |
| InChIKey | OQIQSTLJSLGHID-WNWIJWBNSA-N |
| 密度 | 1.2810 (rough estimate) |
| 熔点 | 268-269 °C |
| 沸点 | 372.21°C (rough estimate) |
| 比旋光度 | D -558° (c = 0.1 in CHCl3); D -480° (c = 0.1 in DMF) |
| 闪点 | 2°C |
| 水溶性 | 15mg/L(temperature not stated) |
| 蒸汽压 | 3.05E-11mmHg at 25°C |
| 溶解度 | 氯仿，二氯甲烷 |
| 折射率 | 1.4800 (estimate) |
| 存储条件 | 2-8°C |
| 稳定性 | 稳定。与强氧化剂不相容。可能对光线或空气敏感。 |
| 外观 | 白色至黄色粉末。 |
| Merck | 13,180 |
| BRN | 1269174 |
| MDL号 | MFCD00869647 |
| 危险品标志 | T+ - 极高毒性物品 T - 有毒物品  Xn - 有害物品  F - 易燃物品  |
| 风险术语 | R45 - 可能致癌。 R46 - 可能引起遗传性基因损害。 R26/27/28 - 吸入、皮肤接触及吞食有极高毒性。 R36 - 刺激眼睛。 R20/21/22 - 吸入、皮肤接触及吞食有害。 R11 - 高度易燃。 R65 - 吞食可能造成肺部损伤。 R48/23/24/25 - R36/38 - 刺激眼睛和皮肤。 R39/23/24/25 - R23/24/25 - 吸入、皮肤接触及吞食有毒。 |
| 安全术语 | S53 - 避免接触，使用前须获得特别指示说明。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S16 - 远离火源。 S24 - 避免皮肤接触。 S7 - 保持容器密封。 S62 - 若吞食，切勿催吐；立即求医，并出示其容器或标签。 S36/37 - 穿戴适当的防护服和手套。 S28 - 不慎与皮肤接触后，立即用大量肥皂水冲洗。 |
| 危险品运输编号 | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | GY1925000 |
| FLUKA BRAND F CODES | 10 |
| 海关编号 | 29322090 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| 上游原料 | 柄曲霉素 |
| 参考资料 展开查看 | 1. 王春燕, 蒋晓青, 周泊. 基于Cu-TPA的电化学生物传感器对黄曲霉毒素B1的检测[J]. 高等学校化学学报, 2019, 40(11). 2. 刘若云,傅春妮,胡婷婷,郑祉迅,秦顺义.壳聚糖硒对饲喂黄曲霉毒素B_1小鼠生长及抗氧化功能的影响[J].养殖与饲料,2020,19(08):40-41. 3. 李满秀, 任光明, 杜丽娟,等. 碳量子点/银复合材料用于食用油中黄曲霉毒素B1的检测[J]. 中国油脂, 2018, 43(4): 53-56. 4. He, B., Yan, X. An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide. Microchim Acta 186, 383 (2019). http://doi.org/10.1 5. Zhao, Qiannan, et al. "Inhibitory Effects of Eurotium cristatum on Growth and Aflatoxin B1 Biosynthesis in Aspergillus flavus." Frontiers in Microbiology 11 (2020): 921.http://doi.org/10.3389/fmicb.2020.00921 6. Sun, Zhiwei, et al. "Functionalized nanoflower-like hydroxyl magnesium silicate for effective adsorption of aflatoxin B1." Journal of hazardous materials 387 (2020): 121792.http://doi.org/10.1016/j.jhazmat.2019.121792 7. Zhiming Sun, Ankang Song, Bin Wang, Gaofeng Wang, Shuilin Zheng,Adsorption behaviors of aflatoxin B1 and zearalenone by organo-rectorite modified with quaternary ammonium salts,Journal of Molecular Liquids,Volume 264,2018,Pages 645-651,ISSN 0167-7322 8. Baoshan He, Xiaohai Yan, A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone, Sensors and Actuators B: Chemical, Volume 290, 2019, Pages 477-483, ISSN 0925-4005, http://doi.org/10.1016/j 9. Baoshan He, Xiaoze Dong, Nb.BbvCI powered DNA walking machine-based Zr-MOFs-labeled electrochemical aptasensor using Pt@AuNRs/Fe-MOFs/PEI-rGO as electrode modification material for patulin detection, Chemical Engineering Journal, Volume 405, 2021, 126642, 10. Wan, Xiaoli, et al. "Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxi cation and antioxidant systems in broiler chickens." (2020). 11. [IF=6.057] Yongmei Jia et al."A label-free fluorescent aptasensor for the detection of Aflatoxin B1 in food samples using AIEgens and graphene oxide."Talanta. 2019 Jun;198:71 12. [IF=1.554] Pinzhu Qin et al."A potential reusable fluorescent aptasensor based on magnetic nanoparticles for ochratoxin A analysis."Open Chem. 2019 Jan;17(1):1301-1308 13. [IF=13.273] Baoshan He et al."Nb.BbvCI powered DNA walking machine-based Zr-MOFs-labeled electrochemical aptasensor using Pt@AuNRs/Fe-MOFs/PEI-rGO as electrode modification material for patulin detection."Chem Eng J. 2021 Feb;405:126642 14. [IF=10.618] Feng Hong et al."Highly sensitive magnetic relaxation sensing method for aflatoxin B1 detection based on Au NP-assisted triple self-assembly cascade signal amplification."Biosens Bioelectron. 2021 Nov;192:113489 15. [IF=10.588] Zhiwei Sun et al."Functionalized nanoflower-like hydroxyl magnesium silicate for effective adsorption of aflatoxin B1."J Hazard Mater. 2020 Apr;387:121792 16. [IF=9.038] Junpeng Zhao et al."Horseradish peroxidase-catalyzed formation of polydopamine for ultra-sensitive magnetic relaxation sensing of aflatoxin B1."J Hazard Mater. 2021 Jun;:126403 17. [IF=7.46] Baoshan He et al."A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone."Sensor Actuat B-Chem. 2019 Jul;290:477 18. [IF=7.46] Long Wang et al."A DNAzyme-assisted triple-amplified electrochemical aptasensor for ultra-sensitive detection of T-2 toxin."Sensor Actuat B-Chem. 2021 Feb;328:129063 19. [IF=5.833] He Baoshan et al."An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide."Microchim Acta. 2019 Jun;186(6):1-10 20. [IF=5.64] Zhao Qiannan et al."Inhibitory Effects of Eurotium cristatum on Growth and Aflatoxin B1 Biosynthesis in Aspergillus flavus."Front Microbiol. 2020 May;0:921 21. [IF=5.373] Han Yan et al."A label-free electrochemical immunosensing platform based on PEI-rGO/Pt@Au NRs for rapid and sensitive detection of zearalenone."Bioelectrochemistry. 2022 Feb;143:107955 22. [IF=3.352] X.L. Wan et al."Protective effects of lycopene on mitochondrial oxidative injury and dysfunction in the liver of aflatoxin B1-exposed broilers."Poultry Sci. 2021 Nov;100:101441 23. [IF=1.749] Md Touhiduzzaman Sarker et al."Evaluation of the protective effect of lycopene on growth performance, intestinal morphology, and digestive enzyme activities of aflatoxinB1 challenged broilers."Anim Sci J. 2021 Jan;92(1):e13540 24. [IF=2.752] Md Touhiduzzaman Sarker et al.Dietary Lycopene Supplementation Could Alleviate Aflatoxin B1 Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers.Animals-Basel. 2021 Nov;11(11):3165 25. [IF=7.312] Yan Li et al."Self-templating construction of flower-like mesoporous magnesium silicate composites from sepiolite for high-efficiency adsorption of aflatoxin B1."Sep Purif Technol. 2022 Jun;291:120953 26. [IF=1.559] Huang Tao et al."Effects of dietary supplementation with Ampelopsis grossedentata extract on production performance and body health of hens."Trop Anim Health Pro. 2022 Feb;54(1):1-14 27. [IF=2.217] Xiaoli Wan et al."Lycopene alleviates aflatoxin B1 induced liver damage through inhibiting cytochrome 450 isozymes and improving detoxification and antioxidant systems in broiler chickens."Ital J Anim Sci. 2022;21(1):31-40 28. [IF=3.591] Liangrui Lv et al."A switchable electrochemical hairpin-aptasensor for ochratoxin A detection based on the double signal amplification effect of gold nanospheres."New J Chem. 2022 Jan;: 29. [IF=4.098] Hongyan Zhang et al."Visual detection of aflatoxin B1 based on specific aptamer recognition combining with triple amplification strategy."Spectrochim Acta A. 2022 Jan;:120862 30. [IF=10.588] Rui Chen et al."Polydopamine nanoparticle-mediated, click chemistry triggered, microparticle-counting immunosensor for the sensitive detection of ochratoxin A."J Hazard Mater. 2022 Apr;428:128206 31. [IF=2.752] Fangju Liu et al."Resveratrol Relieved Acute Liver Damage in Ducks (Anas platyrhynchos) Induced by AFB1 via Modulation of Apoptosis and Nrf2 Signaling Pathways."Animals-Basel. 2021 Dec;11(12):3516 32. [IF=4.35] Sanjun Jin et al."Dietary Curcumin Alleviated Aflatoxin B1-Induced Acute Liver Damage in Ducks by Regulating NLRP3–Caspase-1 Signaling Pathways."Foods. 2021 Dec;10(12):3086 33. [IF=7.514] Supan Cheng et al."Surface-anchored liquid crystal droplets for the semi-quantitative detection of Aflatoxin B1 in food samples."FOOD CHEMISTRY. 2022 Oct;390:133202 |
HSDB 3453 - 简介
黄曲霉素B1是一种由曲霉属真菌产生的毒素，化学名称为霉素H1。其化学结构为多环结构，具有它味苦和若干荧光性质。黄曲霉素B1在自然界广泛存在于发霉的食物，如谷物、坚果、水果等中。
黄曲霉素B1可对动物和人类产生毒性作用。长期摄入或接触黄曲霉素B1可能引发黄曲霉病，导致肝脏损伤、免疫系统抑制、癌症等。人类可通过口腔摄入、吸入或皮肤接触等方式暴露于黄曲霉素B1。
为了保护人类健康，必须遵守严格的安全规范，确保不暴露于黄曲霉素B1。在实验室中使用黄曲霉素B1时，必须遵循正确的实验操作规程，并配备个人防护设备，如手套和防护眼镜，以避免接触。对于工作场所的安全控制，应建立良好的通风系统，并遵循相关的安全操作指南。
黄曲霉素B1可对动物和人类产生毒性作用。长期摄入或接触黄曲霉素B1可能引发黄曲霉病，导致肝脏损伤、免疫系统抑制、癌症等。人类可通过口腔摄入、吸入或皮肤接触等方式暴露于黄曲霉素B1。
为了保护人类健康，必须遵守严格的安全规范，确保不暴露于黄曲霉素B1。在实验室中使用黄曲霉素B1时，必须遵循正确的实验操作规程，并配备个人防护设备，如手套和防护眼镜，以避免接触。对于工作场所的安全控制，应建立良好的通风系统，并遵循相关的安全操作指南。
最后更新：2024-04-09 18:58:34
供应商列表
提供多种规格现货供应
产品名: Aflatoxin B1 去供应商网站查看 询盘CAS: 1162-65-8
产地: 美国
包装: 10 mM * 1 mL;1 mg;5 mg;10 mg
规格: HY-N6615
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.96%
提供多种规格现货供应
产品名: Aflatoxin B1 去供应商网站查看 询盘CAS: 1162-65-8
产地: 美国
包装: 10 mM * 1 mL;1 mg;5 mg;10 mg
规格: HY-N6615
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.96%
HSDB 3453的上游原料
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