AZD3965 由BOC Sciences提供
联系方式
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| 公司名 | BOC Sciences |
| 联系人 | Linna Green |
| 电 话 | +16314854226 |
| 手 机 | +16314854226 |
| 电子邮件 | info@bocsci.com |
| 网 址 | http://www.bocsci.com/ |
| 地 区 | 其他 |
| 邮 编 | 11967 |
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向其他AZD3965供应商询盘
品名: AZD3965
CAS: 1448671-31-5
规格: A872986
包装: 100mg,25mg,5mg,1ml
价格: 5099,2265,785,1221
最后更新: 2026-01-22 17:18:30
CAS: 1448671-31-5
规格: A872986
包装: 100mg,25mg,5mg,1ml
价格: 5099,2265,785,1221
最后更新: 2026-01-22 17:18:30
品名: AZD3965
CAS: 1448671-31-5
规格: HY-12750
包装: 10 mM * 1 mL;2 mg;5 mg;10 mg;25 mg
价格: 询价
产地: 美国
最后更新: 2025-10-14 16:03:33
CAS: 1448671-31-5
规格: HY-12750
包装: 10 mM * 1 mL;2 mg;5 mg;10 mg;25 mg
价格: 询价
产地: 美国
最后更新: 2025-10-14 16:03:33
品名: AZD3965
CAS: 1448671-31-5
规格: IA1640-5mg,5mg,IA1640-10mg,10mg
包装: 盒
价格: 电话、微信、QQ、邮件
产地: 北京
最后更新: 2026-02-10 11:15:19
CAS: 1448671-31-5
规格: IA1640-5mg,5mg,IA1640-10mg,10mg
包装: 盒
价格: 电话、微信、QQ、邮件
产地: 北京
最后更新: 2026-02-10 11:15:19
品名: (S)-5-(4-羟基-4-甲基异恶唑烷-2-羰基)-1-异丙基-3-甲基-6-((5-甲基-3-(三氟甲基)-1H-吡唑-4-基)甲基)噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮
CAS: 1448671-31-5
规格: 98%
包装: 10mg；1mg；25mg；2mg；50mg；5mg
价格: 电话、微信、QQ、邮件
产地: 上海
最后更新: 2026-02-06 09:19:18
CAS: 1448671-31-5
规格: 98%
包装: 10mg；1mg；25mg；2mg；50mg；5mg
价格: 电话、微信、QQ、邮件
产地: 上海
最后更新: 2026-02-06 09:19:18
AZD3965的基本信息
| 中文名 | AZD3965 |
| 英文名 | AZD3965 |
| 别名 | 化合物AZD3965;(S)-5-(4-羟基-4-甲基异恶唑烷-2-羰基)-1-异丙基-3-甲基-6-((5-甲基-3-(三氟甲基)-1H-吡唑-4-基)甲基)噻吩并[2,3-D]嘧啶-2,4(1H,3H)-二酮 |
| CAS | 1448671-31-5 |
| EINECS | |
| 化学式 | C21H24F3N5O5S |
| 分子量 | 515.51 |
| inchi | |
| 包装信息 | 25 mg |
| 价格 | $199 |
| 产品描述 | AZD3965 AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, which is 6-fold selective over MCT2 and does not inhibit MCT4 at 10 μM. Both lactate transport and cell growth are potently inhibited by AZD3965 in lymphoma cell lines that preferentially express MCT1. Lactate transport inhibition in some cell lines also induces a cytotoxic effect. In vitro combination studies show that lactate transport inhibition can enhance the induction of cell death by doxorubicin. Blocking lactate transport in vitro also leads to a rapid inhibition of glucose uptake in the Raji Burkitt's lymphoma cell line. In vivo, AZD3965 is well tolerated and induces a dose- and time-dependent accumulation of lactate in the tumors, suppresses tumor growth and in the Raji model potentiates the effects of Rituxan, doxorubicin and bendamustine. The selective inhibition of lactate transport by the MCT1 inhibitor AZD3965 offers a novel mechanism for targeting the metabolic phenotype in tumors that preferentially express MCT1. |
| 产品链接 | http://www.bocsci.com/product/azd3965-cas-1448671-31-5-463251.html |
| 更新日期 | 2025-04-30 11:27:47 |
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