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| 公司名 | BOC Sciences |
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| 中文名 | PF-06281355 |
| 英文名 | PF-06281355 |
| 别名 | |
| CAS | 1435467-38-1 |
| EINECS | |
| 化学式 | C14H15N3O4S |
| 分子量 | 321.35 |
| inchi | |
| 包装信息 | 50 mg |
| 价格 | $299 |
| 产品描述 | PF-06281355 PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. |
| 产品链接 | http://www.bocsci.com/pf-1355-cas-1435467-38-1-item-474818.html |
| 更新日期 | 2025-04-30 11:27:47 |