p-Nitroacetophenone
p-Nitroacetophenone
CAS: 100-19-6
Molecular Formula: C8H7NO3
p-Nitroacetophenone - Names and Identifiers
| Name | p-Nitroacetophenone |
| Synonyms | AURORA KA-7140 AKOS BBS-00003219 P-NITROACETOPHENONE p-Nitroacetophenone 4-NITROACETOPHENONE 4-Nitroacetophenone p-acetylnitrobenzene 4'-Nitroacetophenone 4'-NITROACETOPHENONE 1-(4-nitrophenyl)ethanone p-nitrophenyl methyl ketone 1-(4-NITROPHENYL)ETHAN-1-ONE 4'-Nitroacetophenone 1-(4-Nitrophenyl)ethan-1-one p-Nitroacetophenone |
| CAS | 100-19-6 |
| EINECS | 202-827-4 |
| InChI | InChI:1S/C8H7NO3/c1-6(10)7-2-4-8(5-3-7)9(11)12/h2-5H,1H3 |
| InChIKey | YQYGPGKTNQNXMH-UHFFFAOYSA-N |
p-Nitroacetophenone - Physico-chemical Properties
| Molecular Formula | C8H7NO3 |
| Molar Mass | 165.15 |
| Density | 1.3450 (rough estimate) |
| Melting Point | 75-78°C(lit.) |
| Boling Point | 202°C(lit.) |
| Flash Point | 201-202°C |
| Water Solubility | Insoluble in water. |
| Vapor Presure | 0.00511mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | Yellow |
| BRN | 607777 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5468 (estimate) |
| Physical and Chemical Properties | The pure character is light yellow crystal or needle crystal. melting point 80~82 ℃ boiling point 202 ℃ solubility soluble in hot ethanol, ether and benzene, insoluble in water. |
| Use | Used as pharmaceutical chloramphenicol intermediates and dye intermediates |
p-Nitroacetophenone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | AM9627000 |
| HS Code | 29147090 |
| Hazard Note | Harmful |
p-Nitroacetophenone - Upstream Downstream Industry
| Raw Materials | Sulfuric acid Nitric acid Ethylbenzene |
| Downstream Products | chloroamphenicol |
p-Nitroacetophenone - Nature
Open Data Verified Data
pure product is light yellow crystal or needle crystal. The melting point was 80-82 °c. Boiling Point 202 °c. Soluble in hot ethanol, ether and benzene, insoluble in water.
Last Update：2025-06-10 22:55:16
p-Nitroacetophenone - Preparation Method
Open Data Verified Data
- ethylbenzene nitrated with mixed acid at 30-35 °c to obtain nitroethylbenzene. After rectification, P-nitroethylbenzene and O-nitroethylbenzene were obtained. P-nitroacetophenone was obtained by the oxidation of p-nitroethylbenzene in the presence of cobalt stearate at 140-150 ℃ and 0.2MPa in air. The reaction product was washed with water, neutralized, centrifuged and dried to obtain a finished product.
- p-nitrobenzoyl chloride method.
Last Update：2022-01-01 10:50:42
p-Nitroacetophenone - Safety
Open Data Verified Data
-
Toxicity was unknown. Production equipment should be sealed, and operators should wear protective equipment.
- the container is packed with plastic bags lined with iron or wood barrels. 25k or 50kg net per barrel. Store in a dry, ventilated place.
Last Update：2025-06-10 22:55:16
p-Nitroacetophenone - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| purpose | used as pharmaceutical chloramphenicol intermediate and dye intermediate organic synthesis intermediate, it is a raw material for the manufacture of medicines such as chloromycetin and chloromycetin. |
| production method | 1. Ethylbenzene Nitration with mixed acid at 30-35 °c to obtain nitration of nitration of nitroethylbenzene. After rectification, P-nitroethylbenzene and O-nitroethylbenzene were obtained. P-nitroethylbenzene is oxidized with air in the presence of the catalyst cobalt stearate at 140-150 °c and a pressure of 0.2MPa to give P-nitroacetophenone. The reaction product was washed with water, neutralized, centrifuged and dried to obtain a finished product. Raw material consumption quota: ethylbenzene 2519kg/t, nitric acid 1535kg/t, sulfuric acid 697kg/t, hydrochloric acid 12kg/t, soda ash 81kg/t, caustic soda 111kg/t, ethanol 100kg/t, methanol 70kg/t. 2. P-nitrobenzoyl chloride method. |
Last Update：2024-04-09 19:55:45
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Raw Materials for p-Nitroacetophenone
Downstream Products for p-Nitroacetophenone