XAV-939 MedChemExpress (MCE)

Product Name	xav-939
Synonyms	CS-300;xav-939;XAV 939;2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one;3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
CAS	284028-89-3
EINECS	687-302-1
Chemical Formula	C14H11F3N2OS
Molecular Weight	312.31
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	XAV-939 XAV-939 MedChemExpress (MCE) HY-15147 284028-89-3 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US Descriptions XAV-939 XAV-939 MedChemExpress (MCE) HY-15147 284028-89-3 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation. XAV-939 has activity against TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively[1]. XAV-939 (0.3-30 μM 3 or 10 days) enhances osteoblast differentiation of hBMSCs[2]. XAV-939 (3 μM) promotes osteoblast differentiation of hMSCs via accumulation of SH3BP2[2]. XAV-939 (3 μM 10 days) upregulates the expression of OPG and downregulates the expression of RANKL in hBMSCs during osteoblast differentiation[2]. XAV-939 suppresses Wnt/β-catenin signaling and promotes SFRP3 and SFRP4 expression[3]. XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo[3]. TNKS2 2 nM (IC50) TNKS1 5 nM (IC50) ARTD2 479 nM (IC50) ARTD1 5500 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24 56(20):7880-9. [Content Brief] [2]. Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7 10(1):16746. [Content Brief] [3]. Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug 161:116445. [Content Brief]
Supplier Website	http://www.medchemexpress.com/XAV-939.html
Last Update	2025-10-14 16:03:33

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