SCH772984 MedChemExpress (MCE)

Product Name	SCH772984
Synonyms	SCH772984 (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5- (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide Synonyms SCH772984 (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5- (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide SCH772984
CAS	942183-80-4
EINECS	1592732-453-0
Chemical Formula	C33H33N9O2
Molecular Weight	587.67
inchi
Package	10 mM * 1 mL;1 mg;2 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	SCH772984 SCH772984 MedChemExpress (MCE) HY-50846 942183-80-4 99.45% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US Descriptions SCH772984 SCH772984 MedChemExpress (MCE) HY-50846 942183-80-4 99.45% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-na?ve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations. SCH772984 (300 nM 24-48hours) results in a G1 arrest in SCH772984-sensitive melanoma cells[1]. SCH772984 (3-300 nM 24 hours) inhibits ERK and RSK phosphorylation[1]. SCH772984 shows EC50 values less than 500 nM in approximately 88% and 49% of BRAF-mutant (n=25) or RAS-mutant (n=35) tumor lines, respectively[1]. SCH772984 (12.5-50 mg/kg i.p. twice daily for 14 days) leads to 98% tumor regression[1]. Dose-dependent antitumor activity is also observed in the KRAS-mutant pancreatic MiaPaCa model, with 36% regression at 50 mg/kg twice daily. Importantly, tumor regression is accompanied by robust inhibition of ERK phosphorylation in tumor tissue. SCH772984 is well tolerated on this schedule as measured by morbidity, lethality, or body weight loss[1]. ERK2 1 nM (IC50) ERK1 4 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Morris EJ, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul 3(7):742-50. [Content Brief]
Supplier Website	http://www.medchemexpress.com/SCH772984.html
Last Update	2025-10-14 16:03:33

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