Hydroxycarbamide MedChemExpress (MCE)

Product Name	Hydroxyurea
Synonyms	HU Hidrix Hydura Hydrea Litaler Hydurea Oxyurea Synonyms HU Hidrix Hydura Hydrea Litaler Hydurea Oxyurea sq 1089 Hydreia Litalir wr 83799 sk 22591 Hydroxyurea Biosupressin Hydroxy urea Hydroxylurea Onco-carbide N-Hydroxyurea N-HYDROXYUREA 1-hydroxyurea Carbamoyl oxime Hydroxycarbamine Hidroxicarbamida Hydroxycarbamide hydrixycarbamide hydroxy urea (d4) Carbamyl hydroxamate Carbamohydroximic acid Carbamohydroxamic acid N-Carbamoylhydroxylamine N-(aminocarbonyl)hydroxylamine
CAS	127-07-1
EINECS	204-821-7
Chemical Formula	CH4N2O2
Molecular Weight	76.05
inchi	InChI=1/CH4N2O2/c2-1(4)3-5/h3H2,(H2,2,4)
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Hydroxyurea Hydroxyurea MedChemExpress (MCE) HY-B0313 127-07-1 Hydroxycarbamide 99.34% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Hydroxyurea Hydroxyurea MedChemExpress (MCE) HY-B0313 127-07-1 Hydroxycarbamide 99.34% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity. Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases[1]. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro[2]. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages[3]. Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice[4]. Mice: To determine whether hydroxyurea would improve anemia and/or prevent or diminish the development of organ damage in the absence of HbF induction, hydroxyurea, at doses of 25 mg/kg, 50 mg/kg, and 100 mg/kg, or vehicle is administered five days per week to SCD mice[4]. HIV-1 \| \| \| \| \| \| \| \| \| \| [1]. Kovacic P, et al. Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan 76(1):24-31. [Content Brief] [2]. Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec 33(12):1486-92. [Content Brief] [3]. Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun 30 Suppl 2:S193-7. [Content Brief] [4]. Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep 95(9):1599-603. [Content Brief] [5]. M B Slabaugh, et al. Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase. J Virol. 1986 Nov 60(2):506-14. [Content Brief]
Supplier Website	http://www.medchemexpress.com/hydroxyurea.html
Last Update	2025-10-14 16:03:33

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