Compound C dihydrochloride; BML-275 dihydrochloride MedChemExpress (MCE)

Product Name	Dorsomorphin 2HCl
Synonyms	BML-275;Dorsomorphin 2HCl;BML-275,Compound C;BML-275 dihydrochloride;Dorsomorphin-2HCl BML-275;dorsoMorphin (Hydrochloride);Dorsomorphin(BML-275)dihydrochloride
CAS	1219168-18-9
EINECS
Chemical Formula	C24H27Cl2N5O
Molecular Weight	472.41008
inchi
Package	10 mM * 1 mL;5 mg;10 mg;20 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Dorsomorphin dihydrochloride Dorsomorphin dihydrochloride MedChemExpress (MCE) HY-13418 1219168-18-9 Compound C dihydrochloride Descriptions Dorsomorphin dihydrochloride Dorsomorphin dihydrochloride MedChemExpress (MCE) HY-13418 1219168-18-9 Compound C dihydrochloride BML-275 dihydrochloride 99.73% 4°C, sealed storage, away from moisture In solvent : -80°C, 1 year -20°C, 6 months (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599). Dorsomorphin (compound C 0-10 μM 18 h) dihydrochloride suppresses 2DG-induced GRP78 promoter activity in human fibrosarcoma HT1080 cells in a dose-dependent manner but has little effect on Tunicamycin (HY-A0098)-induced GRP78 promoter activity. Dorsomorphin dihydrochloride also suppresses GRP78 promoter activity induced by glucose withdrawal. Dorsomorphin dihydrochloride has no effect on 2DG-induced PERK activation and reduces the both basal and 2DG-induced AMPK phosphorylation levels in HT1080 cells[2]. Dorsomorphin (compound C 10 mg/kg, intravenously once) dihydrochloride treatment leads to a 60% increase in total serum iron concentrations, reduces basal levels of hepcidin expression and increases serum iron concentrations in adult mice[3]. Dorsomorphin (0.2 mg/kg, i.v., 30 min before LPS injection) dihydrochloride reduces ICAM-1 and VCAM-1 expression in LPS-injected rat aorta[4]. Dorsomorphin (25 mg/kg i.p. injection, in male BALB/c mice) dihydrochloride treatment before lipopolysaccharide (LPS) injection significantly reduces lethality in contrast to animals treated with LPS challenge only[5]. AMPK 109 nM (Ki) ACVR1 BMPR1A ALK6 Autophagy \| \| \| \| \| \| \| \| \| \| [1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of action. J Clin Invest. 2001 Oct 108(8):1167-74. [Content Brief]* [2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012 7(9):e45845. [Content Brief] [3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan 4(1):33-41. [Content Brief] [4]. Kim YM, et al. Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis. 2011 Nov 219(1):57-64. [Content Brief] [5]. Guo Y, et al. AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury. PLoS One. 2014 Jan 24 9(1):e86881. [Content Brief] [6]. Zhang Y, et al. Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy. Phytomedicine. 2021 Dec 93:153741. [Content Brief]
Supplier Website	http://www.medchemexpress.com/Dorsomorphin-dihydrochloride.html
Last Update	2025-10-14 16:03:33

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