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  6. Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031

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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttp://www.medchemexpress.com/
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Product NameDoxycycline Hyclate
SynonymsDoxycycline Hyclate
Doxycycline Hydrate
Doxycycline Hyclate USP
Doxycycline Hydrochlocide
DOXYCYCLINE HYCLATE USP GRADE
DOXYCYCLINE HYDROCHLORIDE, VETRANAL
Doxycycline Hydrochloride, Vetranal

Synonyms

Doxycycline Hyclate
Doxycycline Hydrate
Doxycycline Hyclate USP
Doxycycline Hydrochlocide
DOXYCYCLINE HYCLATE USP GRADE
DOXYCYCLINE HYDROCHLORIDE, VETRANAL
Doxycycline Hydrochloride, Vetranal
4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Na
4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NA
4-(DIMETHYLAMINO)-1,4,4 ALPHA,5,5 ALPHA,6,11,12 ALPHA-OCTAHYDRO-3,5,10,12,12 ALPHA-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONOHYDRATE
(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride
CAS24390-14-5
EINECS2017-001-1
Chemical FormulaC24H31ClN2O9
Molecular Weight526.97
inchiInChI=1/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29
1-2-3


/h2*4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3
3H,2H2,1H3

inchi

InChI=1/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29
1-2-3


/h2*4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3
3H,2H2,1H3
2*1H
1H2/b2*21-13+



/t2*7-,10+,14+,15-,17-,22-



/m00..../s1
Package10 mM * 1 mL;100 mg;1 g;5 g;10 g;50 g
PriceEmail to quote
DescriptionsDoxycycline hyclate

Doxycycline hyclate

MedChemExpress (MCE)

HY-N0565B

24390-14-5

Doxycycline hydrochloride hemiethanolate hemihydrate

Descriptions

Doxycycline hyclate

Doxycycline hyclate

MedChemExpress (MCE)

HY-N0565B

24390-14-5

Doxycycline hydrochloride hemiethanolate hemihydrate
WC2031

99.19%

4°C, sealed storage, away from moisture and light *In solvent : -80°C, 1 year
-20°C, 6 months (sealed storage, away from moisture and light)

Room temperature in continental US
may vary elsewhere.

Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity.

Doxycycline hyclate (0.01-10 µg/mL, 4 d) affects growth of glioma cells only under high concentrations[2]. Doxycycline hyclate (0.01-10 µg/mL, 24 h) decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells[2]. Doxycycline hyclate (100 ng/mL, 1 µg/mL
24 h) reduces proliferation of human cell lines[4]. Doxycycline hyclate (0-250 μM, 72 h) inhibits cell viability of breast cancer cells [5].

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} Modeling ON-OFF system for gene expression[6][7] Background Doxycycline is often used as an inducer in molecular biology research to induce gene expression. In cells or model animals that have constructed a Tetracycline (Tet
HY-A0107) inducible expression (Tet-ON/Tet-OFF) system, the expression of the target gene can be precisely controlled by adding or removing Doxycycline. Doxycycline can act as an inhibitor of transcriptional activation in the Tetracycline (Tc)-controlled transactivation (tTA) system, and as an inducer of transcriptional activation in the "reverse tTA' system. Doxycycline and Tetracycline both act systemically after being absorbed by the upper gastrointestinal tract. In comparison, the main advantage of Doxycycline is that it has a longer activity and can be taken twice or once a day. Although the peak concentrations of the two are similar, Doxycycline takes a shorter time to reach peak concentration and has a significantly longer half-life [6][7][8]. Specific Mmodeling Methods Rat[8]: male • adult middle-aged (12-month-old) • Sprague-Dawley ratsAdministartion (for GDNF regulation): 3g/kg (Doxycycline
HY-N05655) (dietary with regular food) • po once daily for 6 days • monitored every day Note 1. In this study[7], a recombinant adeno-associated virus (rAAV)-based bicistronic tetracycline (tet)-OFF construct was used for dynamic control of GDNF (target gene) expression during long-term expression. 2. 3g/kg dietary DOX produced DOX serum levels equivalent to 1mg/ml DOX in drinking water. Modeling Record (1) The expression level of the target gene decreases
(2) The positively correlated phenotype corresponding to the target gene is alleviated.

Tetracycline

| | | |

| | | | | |



[1]. Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30
534(7609):647-51. [Content Brief]

[2]. Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17
19(5):1504. [Content Brief]

[3]. Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun
337(3):621-7. [Content Brief]

[4]. Ethan Ahler, et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013 May 31
8(5):e64561. [Content Brief]

[5]. Le Zhang, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017 Apr 18
16(8):737-745. [Content Brief]

[6]. Manfredsson FP, et al. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Mol Ther. 2009 Nov
17(11):1857-67. [Content Brief]

[7]. Kistner A, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A. 1996 Oct 1
93(20):10933-8. [Content Brief]

[8]. Niv Y. Doxycycline in Eradication Therapy of Helicobacter pylori--a Systematic Review and Meta-Analysis. Digestion. 2016
93(2):167-73. [Content Brief]

Supplier Websitehttp://www.medchemexpress.com/Doxycycline-hyclate.html
Last Update2025-10-14 16:03:33
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