Trolox MedChemExpress (MCE)

Product Name	6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
Synonyms	TROLOX troloxc TROLOX(R) TROLOXTM C TIMTEC-BB SBB005933 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid Synonyms TROLOX troloxc TROLOX(R) TROLOXTM C TIMTEC-BB SBB005933 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2-carboxylicaci
CAS	53188-07-1
EINECS	258-422-8
Chemical Formula	C14H18O4
Molecular Weight	250.29
inchi
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Trolox Trolox MedChemExpress (MCE) HY-101445 53188-07-1 99.87% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US Descriptions Trolox Trolox MedChemExpress (MCE) HY-101445 53188-07-1 99.87% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage. Trolox has shown to protect mammalian cells from oxidative damage. Trolox is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion[1]. Trolox could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or post-treatment of cells with Trolox reduced H2O2-induced DNA fragmentation to control levels and below. [2]. Trolox is a hydrophilic analog of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator[3]. Thymocytes are treated with Trolox (10 mM) before, during, or after 10 min exposure to 10 μM H2O2. Trolox incubations that are conducted before or after H2O2 exposures are performed in TCM. Trolox treatments that are administered concurrently with H2O2 are performed in PBS with ferrous sulfate[1]. \| \| \| \| \| \| \| \| \| \| [1]. Mickle DA, et al. Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction. Ann Thorac Surg. 1989 Apr 47(4):553-7. [Content Brief] [2]. Forrest VJ, et al. Oxidative stress-induced apoptosis prevented by Trolox. Free Radic Biol Med. 1994 Jun 16(6):675-84. [Content Brief] [3]. Wu TW, et al. The cytoprotective effect of Trolox demonstrated with three types of human cells. Biochem Cell Biol. 1990 Oct 68(10):1189-94. [Content Brief]
Supplier Website	http://www.medchemexpress.com/Trolox.html
Last Update	2025-10-14 16:03:33

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