TZP-101 MedChemExpress (MCE)

Product Name	TZP 101
Synonyms	TZP 101;UliMorelin;(7R,10R,13S,16R)-13-cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11,16-trimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CAS	842131-33-3
EINECS
Chemical Formula	C30H39FN4O4
Molecular Weight	538.6534632
inchi
Package	1 mg
Price	Email to quote
Descriptions	Ulimorelin Ulimorelin MedChemExpress (MCE) HY-14903 842131-33-3 TZP-101 96.10% Powder -20掳C 3 years In solvent -80掳C 6 months -20掳C 1 month Room temperature in continental US Descriptions Ulimorelin Ulimorelin MedChemExpress (MCE) HY-14903 842131-33-3 TZP-101 96.10% Powder -20掳C 3 years In solvent -80掳C 6 months -20掳C 1 month Room temperature in continental US may vary elsewhere. Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at 伪1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition. Ulimorelin (TZP-101 0.3-5 mg/kg i.v.) causes a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum[1]. Ulimorelin (1, 3, 5 mg/kg i.v.) causes a substantial and prolonged (~1 h) increase in colorectal propulsive activity and expulsion of colonic contents[1]. Ulimorelin (p.o. 8 mg/kg) has a Cmax of 0.39 渭M and a AUC of 82 渭M鈥in for rats. Ulimorelin (i.v. 2 mg/kg) has a T1/2 of 50 mins, a CL of 24 mL/min/kg, and a Vss of 1.7 L/kg for rats[3]. \| \| \| \| \| \| \| \| \| \| [1]. Pustovit RV, et al. The聽mechanism聽of聽enhanced聽defecation聽caused聽by the聽ghrelin聽receptor聽agonist,聽ulimorelin. Neurogastroenterol Motil.聽2014 Feb 26(2):264-71. [Content Brief] [2]. Broad J, et al. Analysis of the ghrelin receptor-independent vascular actions of ulimorelin. Eur J Pharmacol.聽2015聽Apr 5 752:34-9.聽 [Content Brief] [3]. Hoveyda HR, et al. Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic. J Med Chem. 2011 Dec 22 54(24):8305-20. [Content Brief]
Supplier Website	http://www.medchemexpress.com/ulimorelin.html
Last Update	2025-10-14 16:03:33

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-10-14 16:03:33

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-10-14 16:03:33

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-10-14 16:03:33

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-10-14 16:03:33

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-10-14 16:03:33

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-10-14 16:03:33

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-10-14 16:03:33

Thalidomide-PEG4-NH2

Category: Signaling Pathways
CAS: 2387510-82-7
Last Update: 2025-10-14 16:03:33


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	http://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact