Poly(I:C) sodium MedChemExpress (MCE)

Product Name	polyinosinic-polycytidylic acid sodium
Synonyms	POLY I POLY C, NA Polymyocyte sodium salt POLY[I] POLY[C] SODIUM SALT polyinosinic-polycytidylic acid sodium POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT Polyinosinic-Polycytidylic Acid Sodium Salt Synonyms POLY I POLY C, NA Polymyocyte sodium salt POLY[I] POLY[C] SODIUM SALT polyinosinic-polycytidylic acid sodium POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT Polyinosinic-Polycytidylic Acid Sodium Salt POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT POLYINOSINIC ACID + POLYCYTIDYLIC ACID, SODIUM SALT Polyinosinic Acid . Polycytidylic Acid, Sodium Salt, Double Oligochitosan-kanamycin-polyI-polyC sodium salt compound solution Polyinosinic acid - polycytidylic acid sodium salt, double-stranded
CAS	42424-50-0
EINECS	1308068-626-2
Chemical Formula	C19H27N7O16P2
Molecular Weight	671.41
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium MedChemExpress (MCE) HY-135748 42424-50-0 Poly(I:C) sodium 99.40% -20°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium MedChemExpress (MCE) HY-135748 42424-50-0 Poly(I:C) sodium 99.40% -20°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis. Polyinosinic-polycytidylic acid (20 ng/mL 24 hours WM793, WM278, WM239A, WM9 and 1205Lu cells) treatment strongly reduces viability from 100% in controls to 20%–50% within 24 hours[1]. Polyinosinic-polycytidylic acid (200 ng/mL 24 hours 1205Lu cells) treatment induces apoptosis in 1205Lu cells[1]. Polyinosinic-polycytidylic acid (3 ng/mL 24 hours 1205Lu cells) treatment induces IFN-β expression in melanoma cells. Silencing of RIG-I and MDA-5 confirmed that induction of IFN-β by Polyinosinic-polycytidylic acid required RIG-I and MDA-5, respectively, and that required IPS-1[1]. Polyinosinic-polycytidylic acid (5 ng/mL 24 hours 1205Lu cells) treatment reveals active subunits of caspase-9 and caspase-8 in melanoma cells[1]. Polyinosinic-polycytidylic acid sodium is prepared for injection by resuspending in sterile saline, heating to 50 °C at a concentration of 2 mg/mL to ensure complete solubilisation and then allowing to cool naturally to room temperature to ensure proper annealing of double-stranded RNA. Polyinosinic-polycytidylic acid is stored at -20 °C until use[3]. Polyinosinic-polycytidylic acid treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid[1]. TLR3 \| \| \| \| \| \| \| \| \| \| [1]. Besch R, et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest. 2009 Aug 119(8):2399-411. [Content Brief] [2]. Cheng YS, et al. Anticancer function of polyinosinic-polycytidylic acid. Cancer Biol Ther. 2010 Dec 15 10(12):1219-23. [Content Brief] [3]. Robert Field, et al. Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration. Brain Behav Immun. 2010 Aug 24(6):996-1007. [Content Brief]
Supplier Website	http://www.medchemexpress.com/polyinosinic-polycytidylic-acid-sodium.html
Last Update	2025-10-14 16:03:33

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