Ursodeoxycholic acid MedChemExpress (MCE)

Product Name	Ursodeoxycholic acid
Synonyms	UDCA URSODIOL Ursodiol Tauroursodiol URSODEOXYCHOLIC ACID URSODEOXYCHOLOC ACID Ursodeoxycholic acid Synonyms UDCA URSODIOL Ursodiol Tauroursodiol URSODEOXYCHOLIC ACID URSODEOXYCHOLOC ACID Ursodeoxycholic acid URSODESOXYCHOLIC ACID Urosodeoxycholic Acid 3,7-Dihydroxycholan-24-oic acid Ursodeoxycholic acid(micronized) 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oate (3alpha,5alpha,7beta)-3,7-dihydroxycholan-24-oate (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid (3alpha,5beta,7alpha)-3,7-dihydroxycholan-24-oic acid (3alpha,5beta,7beta,8xi,9xi,14xi)-3,7-dihydroxycholan-24-oic acid (4R)-4-[(3R,5S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3R,5S,7S,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS	128-13-2
EINECS	204-879-3
Chemical Formula	C24H40O4
Molecular Weight	392.57
inchi	InChI=1/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15-,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Ursodeoxycholic acid Ursodeoxycholic acid MedChemExpress (MCE) HY-13771 128-13-2 Ursodeoxycholate Descriptions Ursodeoxycholic acid Ursodeoxycholic acid MedChemExpress (MCE) HY-13771 128-13-2 Ursodeoxycholate Ursodiol UDCA 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active. Ursodeoxycholic acid (10 μM 24 h) reduces ACE2 and SHP levels in primary airway and intestinal organoids, and reduces SARS-CoV-2 infection in multiple cell types via FXR-mediated ACE2 regulation[4]. Ursodeoxycholic acid (50, 150, and 450 mg/kg p.o. daily for 21 days) results in weight loss in C57BL/6J wildtype mice[1]. Ursodeoxycholic acid (1% w/w or 416 mg/kg oral 7 days) reduces ACE2 expression in mice and hamsters[4]. Ursodeoxycholic acid (416 mg/kg oral 7 days) reduces SARS-CoV-2 infection in hamsters[4]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Winston JA, et al. Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice. PLoS One. 2021 16(2):e0246161. Published 2021 Feb 18. [Content Brief] [2]. Jackson H, et al. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct 46(4):1131-7. [Content Brief] [3]. Kumar D, et al. Use of ursodeoxycholic acid in liver diseases. J Gastroenterol Hepatol. 2001 Jan 16(1):3-14. [Content Brief] [4]. Brevini T, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5. [Content Brief] [5]. Biao Nie, et al. Specific Bile Acids Inhibit Hepatic Fatty Acid Uptake in Mice. Hepatology. 2012 Oct 56(4):1300-10. [Content Brief]
Supplier Website	http://www.medchemexpress.com/Ursodiol.html
Last Update	2025-10-14 16:03:33

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