L-Ascorbic acid MedChemExpress (MCE)

Product Name	L(+)-Ascorbic acid
Synonyms	VC Vit.C Vitamin C Vitamine C ascorbic acid Vita C BP2005 L(+)-Ascorbic Acid Synonyms VC Vit.C Vitamin C Vitamine C ascorbic acid Vita C BP2005 L(+)-Ascorbic Acid L(+)-Ascorbic acid L-(+)-Ascorbic acid L-Ascorbic Acid, Free Acid L-threo-hex-1-enofuranos-3-ulose 5-(1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one (non-preferred name) (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one (non-preferred name)
CAS	50-81-7
EINECS	200-066-2
Chemical Formula	C6H8O6
Molecular Weight	176.12
inchi	InChI=1/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2
Package	10 mM * 1 mL;500 mg;1 g
Price	Email to quote
Descriptions	L-Ascorbic acid L-Ascorbic acid MedChemExpress (MCE) HY-B0166 50-81-7 L-Ascorbate Descriptions L-Ascorbic acid L-Ascorbic acid MedChemExpress (MCE) HY-B0166 50-81-7 L-Ascorbate Vitamin C 99.97% RT, protect from light In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of L-Ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L-ascorbic acid. L-Ascorbic acid (0.1 μM-2 mM) exhibits anti-cancer effects according to SVCT-2 expression and L-ascorbic acid uptake. Human colorectal cancer cell lines displays differential responses to L-ascorbic acid, primarily depending on the expression level of SVCT-2[4]. L-Ascorbic acid/Tolbutamide produces hypoglycaemic activity in a dose dependant manner in normal (60 mg/kg) and diabetic (40 mg/kg) condition. In the presence of L-ascorbic acid, Tolbuatmide (20 mg/kg) produces early onset of action and maintained for longer period compared to Tolbutamide matching control[5]. T-type calcium channel Microbial Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb 22(1):18-35. [Content Brief] [2]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14 27(46):12577-83. [Content Brief] [3]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep 75(3):173-82. [Content Brief] [4]. Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27 8(1):11372. [Content Brief] [5]. Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3 5(1):2. [Content Brief]
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Last Update	2025-10-14 16:03:33

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