Corticosterone MedChemExpress (MCE)

Product Name	corticosterone
Synonyms	KENDALL'S 'B' corticosterone KENDALL'S COMPOUND B 21-Dihydroxyprogesterone 11,12-dihydroxyprogesterone 4-Pregnen-11?21-diol-3,20-dione 11BETA,21-DIHYDROXY-PROGESTERONE Synonyms KENDALL'S 'B' corticosterone KENDALL'S COMPOUND B 21-Dihydroxyprogesterone 11,12-dihydroxyprogesterone 4-Pregnen-11?21-diol-3,20-dione 11BETA,21-DIHYDROXY-PROGESTERONE 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE 11BETA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE 11-beta,21-dihydroxypregn-4-ene-3,20-dione (11BETA)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE (11beta)-11,21-dihydroxypregn-4-ene-3,20-dione
CAS	50-22-6
EINECS	200-019-6
Chemical Formula	C21H30O4
Molecular Weight	346.47
inchi	InChI=1/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
Package	10 mM * 1 mL;10 mM * 1 mL;50 mg;50 mg;100 mg;100 mg
Price	Email to quote
Descriptions	Corticosterone Corticosterone MedChemExpress (MCE) HY-B1618 50-22-6 17-Deoxycortisol Descriptions Corticosterone Corticosterone MedChemExpress (MCE) HY-B1618 50-22-6 17-Deoxycortisol 11β,21-Dihydroxyprogesterone Kendall's compound B 99.76% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect. Corticosterone (100 nM 30 min) via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane[1]. Corticosterone (CORT) (1 µM 48 h) shows good immunosuppressive properties (functionally compromises maturation of BMDC), which impairs LPS-induced up-regulation of maturation-associated markers (MHC class II, B7.2, B7.1 and CD40)[2]. Corticosterone results in a marked reduction in the ability of BMDC cells to prime naive CD8+ T cells in vivo[2]. Corticosterone (0.03 or 1 mg/kg s.c. single) downregulates expression of BDNF mRNA in dentate gyrus and CA1 of rats[3]. Corticosterone (2.6 mg/kg in animal feedings 8 days) restores ethanol intake and preference to approximately normal preoperative levels in adrenalectomy (ADX) rats[4]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Elftman MD, et al. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007 Oct 122(2):279-90. [Content Brief] [2]. Schaaf MJ, et al. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res. 1998 Nov 30 813(1):112-20. [Content Brief] [3]. Fahlke C, et al. Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol. 1994 May-Jun 11(3):195-202. [Content Brief]
Supplier Website	http://www.medchemexpress.com/Corticosterone.html
Last Update	2025-10-14 16:03:33

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