HP-β-CD MedChemExpress (MCE)

Product Name	Hydroxypropyl-beta-cyclodextrin
Synonyms	HBC HPCD HPBCD hpbcd HP-beta-cyclodextrin HYDROXYPROPYL-β-CYCLODEXTRIN Hydroxypyle beta cyclodextrin Synonyms HBC HPCD HPBCD hpbcd HP-beta-cyclodextrin HYDROXYPROPYL-β-CYCLODEXTRIN Hydroxypyle beta cyclodextrin HYDROXYPROPYL-BETA-CYCLODEXTRIN Hydroxypropyl-beta-cyclodextrin 2-hydroxypropyl-beta-cyclodextrin 2-Hydroxypropy-.beta.-cyclodextrin (2-hydroxypropyl)-beta-cyclodextrin beta-Cyclodextrin, 2-hydroxypropyl ether beta-Cyclodextrin 2-hydroxypropyl ethers
CAS	94035-02-6;128446-35-5;136019-12-0
EINECS	618-994-5
Chemical Formula	C54H102O39
Molecular Weight	1375.36
inchi	InChI=1/C105H196O56/c1-50(106)22-127-43-71-78-85(134-29-57(8)113)92(141-36-64(15)120)99(148-71)156-79-72(44-128-23-51(2)107)150-101(94(143-38-66(17)122)86(79)135-30-58(9)114)158-81-74(46-130-25-53(4)109)152-103(96(145-40-68(19)124)88(81)137-32-60(11)116)160-83-76(48-132-27-55(6)111)154-105(98(147-42-70(21)126)90(83)139-34-62(13)118)161-84-77(49-133-28-56(7)112)153-104(97(146-41-69(20)125)91(84)140-35-63(14)119)159-82-75(47-131-26-54(5)110)151-102(95(144-39-67(18)123)89(82)138-33-61(12)117)157-80-73(45-129-24-52(3)108)149-100(155-78)93(142-37-65(16)121)87(80)136-31-59(10)115/h50-126H,22-49H2,1-21H3
Package	500 mg;1 g;5 g;10 g
Price	Email to quote
Descriptions	HP-β-CD HP-β-CD MedChemExpress (MCE) HY-101103 128446-35-5 (2-Hydroxypropyl)-β-cyclodextrin 99.74% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions HP-β-CD HP-β-CD MedChemExpress (MCE) HY-101103 128446-35-5 (2-Hydroxypropyl)-β-cyclodextrin 99.74% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. HP-β-CD ((2-Hydroxypropyl)-β-cyclodextrin) is a widely used drug delivery vehicle to improve the stability and bioavailability. Cell treatment with HP-β-CD results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity[1]. HP-β-CD treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for HP-β-CD after 72 hours exposure are in the range of 3.86-10.09 mM. HP-β-CD also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by HP-β-CD[2]. HP-β-CD administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder[1]. Intraperitoneal injection of HP-β-CD significantly improves survival in leukemia mouse models. Systemic administration of HP-β-CD to mice has no significant adverse effects[2]. Mice: Mice are intraperitoneally injected with 200 μL vehicle (saline) or (2-Hydroxypropyl)-β-cyclodextrin (50 or 150 mM) for 20 consecutive days 3 days after transplantation, and survival is monitored daily. Leukemic cell engraftment is confirmed by detection of GFP-positive cells in the recipient’s BM using flow cytometry[2]. Cells are incubated with HP-β-CD at various concentrations (5, 7.5, 10, 15, 20 mM) for 72 hours. Cell viability is assessed using a trypan blue dye exclusion method and cell proliferation is evaluated using a modified methyl-thiazol-diphenyl- tetrazolium (MTT) assay[2]. \| \| \| \| \| \| \| \| \| \| [1]. Song W, et al. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4 289(14):10211-22. [Content Brief] [2]. Yokoo M, et al. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4 10(11):e0141946. [Content Brief]
Supplier Website	http://www.medchemexpress.com/hp-β-cd.html
Last Update	2025-10-14 16:03:33

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