25-Hydroxycholesterol MedChemExpress (MCE)

Product Name	(3beta,9beta,14beta)-cholest-5-ene-3,25-diol
Synonyms	25-HYDROXYCHOLESTEROL 5-cholestene-3β,25-diol 5-CHOLESTENE-3BETA,25-DIOL 5-CHOLESTEN-3-BETA, 25-DIOL 3BETA,25-DIHYDROXY-5-CHOLESTENE Cholest-5-ene-3,25-diol, (3.beta.)- 25-Hydroxycholesterol (not deuterated) Synonyms 25-HYDROXYCHOLESTEROL 5-cholestene-3β,25-diol 5-CHOLESTENE-3BETA,25-DIOL 5-CHOLESTEN-3-BETA, 25-DIOL 3BETA,25-DIHYDROXY-5-CHOLESTENE Cholest-5-ene-3,25-diol, (3.beta.)- 25-Hydroxycholesterol (not deuterated) (3beta,9beta,14beta)-cholest-5-ene-3,25-diol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS	2140-46-7
EINECS
Chemical Formula	C27H46O2
Molecular Weight	402.65
inchi	InChI=1/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23-,24-,26+,27-/m1/s1
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	25-Hydroxycholesterol 25-Hydroxycholesterol MedChemExpress (MCE) HY-113134 2140-46-7 25-OHC 99.98% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 25-Hydroxycholesterol 25-Hydroxycholesterol MedChemExpress (MCE) HY-113134 2140-46-7 25-OHC 99.98% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells. The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec 88(6):1071-2. [Content Brief]
Supplier Website	http://www.medchemexpress.com/25-Hydroxycholesterol.html
Last Update	2025-10-14 16:03:33

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