8,11,14-Eicosatriynoic acid MedChemExpress (MCE)

Product Name	8,11,14-Eicosatriynoic Acid
Synonyms	8,11,14-Eicosatriynoic Acid;QLLIWTBTVOPGCM-UHFFFAOYSA-N
CAS	34262-64-1
EINECS
Chemical Formula	C20H28O2
Molecular Weight	300.44
inchi
Package	5 mg
Price	Email to quote
Descriptions	8,11,14-Eicosatriynoic acid 8,11,14-Eicosatriynoic acid MedChemExpress (MCE) HY-131384 34262-64-1 8,11,14-Icosatriynoic acid Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions 8,11,14-Eicosatriynoic acid 8,11,14-Eicosatriynoic acid MedChemExpress (MCE) HY-131384 34262-64-1 8,11,14-Icosatriynoic acid Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. 8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization. 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. \| \| \| \| \| \| \| \| \| \| [1]. Goetz JM, et al. Inhibition of prostaglandin biosynthesis by triynoic acids. Prostaglandins. 1976 Aug 12(2):187-92. [Content Brief] [2]. Sun FF, et al. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. Prostaglandins. 1981 Feb 21(2):333-43. [Content Brief] [3]. Fitzpatrick F A. Cyclooxygenase enzymes: regulation and function[J]. Current pharmaceutical design, 2004, 10(6): 577-588.
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Last Update	2025-10-14 16:03:33

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