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Supplier NameMedChemExpress (MCE)
Contactsales
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Emailsales@medchemexpress.com; tech@medchemexpress.com
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Product NameZinc Protoporphyrin
SynonymsZinc Protoporphyrin
CAS15442-64-5
EINECS
Chemical FormulaC34H32N4O4Zn
Molecular Weight626.04
inchi
Package10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
PriceEmail to quote
DescriptionsZinc Protoporphyrin

Zinc Protoporphyrin

MedChemExpress (MCE)

HY-101193

15442-64-5

Zn(II)-protoporphyrin IX

Descriptions

Zinc Protoporphyrin

Zinc Protoporphyrin

MedChemExpress (MCE)

HY-101193

15442-64-5

Zn(II)-protoporphyrin IX
ZnPP
Zinc Protoporphyrin-9

99.87%

-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months
-20°C, 1 month (sealed storage, away from moisture)

Room temperature in continental US
may vary elsewhere.

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.

to increase in Protoporphyrin (Zn(II)-protoporphyrin IX
5 μM
72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h[3]. Zinc Protoporphyrin (1.25-40 μM
48 or 72 hours) exerts cytostatic/cytotoxic effects against tumor cells[3]. Zinc Protoporphyrin (2.5, 5 μM
48 or 72 hours) results in dose- and time-dependent reduction of cells in the G1 phase of the cell cycle[3]. Zinc Protoporphyrin (1.25-40 μM
48 hours) leads to the accumulation of cleaved (active) caspase-3[3].

Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.
12.5, 50 mg/kg for p.o.
from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth[3].

Human Endogenous Metabolite

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[1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13
17(4). [Content Brief]

[2]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26
12:229. [Content Brief]

[3]. Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11
8:197. [Content Brief]

Supplier Websitehttp://www.medchemexpress.com/zinc-protoporphyrin.html
Last Update2025-10-14 16:03:33
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