EGTA MedChemExpress (MCE)

Product Name	Egtazic acid
Synonyms	ebonta Egtazic acid 1,2-bis(2-dicarboxymethylaminoethoxy)ethane ethylenedioxybis(ethyleneamino)tetraaceticacid 3,6-DIOXAOCTAMETHYLENEDINITRILOTETRAACETIC ACID Ethylene glycol-bis-(2-aminoethyl)tetraacetic acid Synonyms ebonta Egtazic acid 1,2-bis(2-dicarboxymethylaminoethoxy)ethane ethylenedioxybis(ethyleneamino)tetraaceticacid 3,6-DIOXAOCTAMETHYLENEDINITRILOTETRAACETIC ACID Ethylene glycol-bis-(2-aminoethyl)tetraacetic acid 12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-9-dioxa-3 9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-6 ETHYLENE GLYCOL BIS-(BETA-AMINOETHYLETHER)-N,N,N',N'-TETRAACETIC 6,9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid 3,12-bis(carboxylatomethyl)-6,9-dioxa-3,12-diazoniatetradecane-1,14-dioate
CAS	67-42-5
EINECS	200-651-2
Chemical Formula	C14H24N2O10
Molecular Weight	380.35
inchi	InChI=1/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)/p-2
Package	500 mg;1 g
Price	Email to quote
Descriptions	EGTA EGTA MedChemExpress (MCE) HY-D0861 67-42-5 98.0% Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions EGTA EGTA MedChemExpress (MCE) HY-D0861 67-42-5 98.0% Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages. EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2]. \| \| \| \| \| \| \| \| \| \| [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994 267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426 [Content Brief] [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003 29(3):211-213. [Content Brief]
Supplier Website	http://www.medchemexpress.com/egta.html
Last Update	2025-10-14 16:03:33

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