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  6. BAMEA-O16B

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Supplier Contact

Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttp://www.medchemexpress.com/
Wechat
Product NameBAMEA-O16B
SynonymsBAMEA-O16B
CAS2490668-30-7
EINECS
Chemical FormulaC56H111N3O6S6
Molecular Weight1114.88
inchi
Package5 mg;10 mg;25 mg;50 mg
PriceEmail to quote
DescriptionsBAMEA-O16B

BAMEA-O16B

MedChemExpress (MCE)

HY-139306

2490668-30-7

98.0%

-20°C, stored under nitrogen *In solvent : -80°C, 6 months

Descriptions

BAMEA-O16B

BAMEA-O16B

MedChemExpress (MCE)

HY-139306

2490668-30-7

98.0%

-20°C, stored under nitrogen *In solvent : -80°C, 6 months
-20°C, 1 month (stored under nitrogen)

Room temperature in continental US
may vary elsewhere.

BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing.

BAMEA-O16B/Cas9 mRNA/sgHPV18 (HeLa cells) treatment significantly prohibits HeLa growth compared to that of a scramble sgRNA and Cas9 mRNA delivery. BAMEA-O16B shows RNA delivery efficiency. BAMEA-O16B shows mRNA encapsulation efficiency. BAMEA-O16B shows GFP knockout efficiency. BAMEA-O16B mediated Cas9mRNA delivery is able to regulate endogenous gene expression. BAMEA-O16B/RNA treated cells shows a higher endosome escape efficiency than that of BAMEA-O16/RNA treatment. BAMEA-O16B/RFP mRNA (HeLa cells) nanoparticles results in efficient RFP expression[1].

BAMEA-O16B/Cas9 mRNA/sgRNA (I.v.) nanoparticle effectively knocks mouse serum proprotein convertase subtilisin/kexin type 9 (PCSK9) level down to 20% of nontreated mouse. BAMEA-O16B/Cas9 mRNA/sgPCSK9 nanoparticle reduces mouse serum PCSK9 down to 20% of that with DPBS injection or BAMEA-O16B/Cas9 mRNA/scramblesgRNA nanoparticle injections[1].

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[1]. Liu J, et al. Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles. Adv Mater. 2019
31(33):e1902575. [Content Brief]

Supplier Websitehttp://www.medchemexpress.com/bamea-o16b.html
Last Update2025-10-14 16:03:33
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