EGTA tetrasodium MedChemExpress (MCE)

Product Name	EGTA tetrasodium
Synonyms	EGTA tetrasodium EGTA TETRASODIUM EGTA TETRASODIUM SALT ethylene glycol-bis(B-aminoethylether)-N,N,N',N' ETHYLENE GLYCOL-BIS(B-AMINOETHYLETHER)- N,N,N',N'-T ETHYLENEGLYCOL-BIS(B-AMINOETHYLETHER)-N,N,NNTETRAACETICACIDTETRASODIUMSALT Synonyms EGTA tetrasodium EGTA TETRASODIUM EGTA TETRASODIUM SALT ethylene glycol-bis(B-aminoethylether)-N,N,N',N' ETHYLENE GLYCOL-BIS(B-AMINOETHYLETHER)- N,N,N',N'-T ETHYLENEGLYCOL-BIS(B-AMINOETHYLETHER)-N,N,NNTETRAACETICACIDTETRASODIUMSALT ethylene glycol-bis(β-aminoethyl ether)-n,n,n',n'-tetraacetic acid tetrasodium salt ETHYLENE GLYCOL-BIS(BETA-AMINOETHYL ETHER)-N,N,N',N'-TETRAACETIC ACID TETRASODIUM SALT EGTA tetrasodium, Egtazic acid tetrasodium, Ethylene-bis(oxyethylenenitrilo)tetraacetic acid tetrasodium
CAS	13368-13-3
EINECS
Chemical Formula	C14H20N2Na4O10
Molecular Weight	468.28
inchi
Package	Inquiry
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Descriptions	EGTA tetrasodium EGTA tetrasodium MedChemExpress (MCE) HY-D0861A 13368-13-3 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions EGTA tetrasodium EGTA tetrasodium MedChemExpress (MCE) HY-D0861A 13368-13-3 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages. EGTA tetrasodium, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA tetrasodium concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2]. \| \| \| \| \| \| \| \| \| \| [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994 267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426. [Content Brief] [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003 29(3):211-213. [Content Brief]
Supplier Website	http://www.medchemexpress.com/egta-tetrasodium.html
Last Update	2025-10-14 16:03:33

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