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Lipopolysaccharides, from S. enterica serotype typhimuriumMCE China：Lipopolysaccharides, from S. enterica serotype typhimurium
Brand：MedChemExpress (MCE)
Cat. No.HY-D1056C3
Synonyms：LPS, from Salmonella enterica (Serotype typhimurium)
Storage：Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping：Room temperature in continental US
may vary elsewhere.
Description：Lipopolysaccharides, from S. enterica serotype typhimurium, are a kind of lipid-polysaccharide endotoxin. Smooth Gram-negative bacteria's lipopolysaccharides are made up of three components: lipid A, core oligosaccharide, and O antigen (OAg). The O antigen is a polymer of sugar repeat units (RUs)
the Wzz protein regulates the length of the O antigen in lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz protein. S. enterica typhimurium has two Wzz proteins: WzzST (which makes the modal range of the O antigen between 16 and 35 RUs) and WzzfepE (which makes the modal value over 100 RUs). Mutating the genes corresponding to these two proteins causes the formation of short-chain O antigen chains and significantly reduces bacterial pathogenicity.
IC50 & Target：TLR-4[2] SMILES [Lipopolysaccharides, from S. enterica serotype typhimurium]
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References：
[1]. Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr
75(4):383-404.
[Content Brief]
[2]. Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov
58:327-337.
[Content Brief]
[3]. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct
30(2):221-32.
[Content Brief]
[4]. Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov
6(6):422-433.
[Content Brief]
[5]. Guard-Bouldin J,et al. Subpopulation characteristics of egg-contaminating Salmonella enterica serovar Enteritidis as defined by the lipopolysaccharide O chain[J]. Applied and environmental microbiology, 2004, 70(5): 2756-2763.
[6]. Murray G L, et al. Altering the length of the lipopolysaccharide O antigen has an impact on the interaction of Salmonella enterica serovar Typhimurium with macrophages and complement[J]. Journal of bacteriology, 2006, 188(7): 2735-2739.
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