CDK6 Antibody (YA6286) MedChemExpress (MCE)

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Supplier Name	MedChemExpress (MCE)
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Product Name	CDK6 Antibody (YA6286)
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Descriptions	MCE products for research use only. We do not sell to patients. CDK6 Antibody (YA6286) MCE China：CDK6 Antibody (YA6286) Brand：MedChemExpress (MCE) Cat. No.HY-P86594 Shipping：Shipping with blue ice. Background：The CDK6ic complex, a serine/threonine-protein kinase, assumes a pivotal role in cell cycle regulation and differentiation, specifically promoting the G1/S transition. This complex exerts its regulatory influence by phosphorylating critical substrates such as pRB/RB1 and NPM1. During interphase, the CDK6 interacts with D-type G1 cyclins, forming an active pRB/RB1 kinase and governing entry into the cell cycle. Notably, this complex is intricately involved in both the initiation and maintenance of cell cycle exit during cellular differentiation, acting as a negative regulator of cell differentiation while remaining essential for the proliferation of specific cell types, including erythroid and hematopoietic cells. Its indispensable role extends to thymocyte development and the promotion of newborn neuron production. Furthermore, in astrocytes, the CDK6-CCND1 complex facilitates changes in gene expression patterns, modulates the actin cytoskeleton, and enhances motility during cell differentiation. Importantly, it exerts regulatory control over myeloid differentiation and delays senescence, highlighting its diverse and crucial functions in cellular processes. Additionally, the complex plays a role in promoting beta-cell proliferation in the pancreatic islets of Langerhans and may contribute to centrosome organization during various cell cycle phases. Host：Rabbit Reactivity：Human Dilution Ratio：IHC: 1:200-1000 Descriptions MCE products for research use only. We do not sell to patients. CDK6 Antibody (YA6286) MCE China：CDK6 Antibody (YA6286) Brand：MedChemExpress (MCE) Cat. No.HY-P86594 Shipping：Shipping with blue ice. Background：The CDK6ic complex, a serine/threonine-protein kinase, assumes a pivotal role in cell cycle regulation and differentiation, specifically promoting the G1/S transition. This complex exerts its regulatory influence by phosphorylating critical substrates such as pRB/RB1 and NPM1. During interphase, the CDK6 interacts with D-type G1 cyclins, forming an active pRB/RB1 kinase and governing entry into the cell cycle. Notably, this complex is intricately involved in both the initiation and maintenance of cell cycle exit during cellular differentiation, acting as a negative regulator of cell differentiation while remaining essential for the proliferation of specific cell types, including erythroid and hematopoietic cells. Its indispensable role extends to thymocyte development and the promotion of newborn neuron production. Furthermore, in astrocytes, the CDK6-CCND1 complex facilitates changes in gene expression patterns, modulates the actin cytoskeleton, and enhances motility during cell differentiation. Importantly, it exerts regulatory control over myeloid differentiation and delays senescence, highlighting its diverse and crucial functions in cellular processes. Additionally, the complex plays a role in promoting beta-cell proliferation in the pancreatic islets of Langerhans and may contribute to centrosome organization during various cell cycle phases. Host：Rabbit Reactivity：Human Dilution Ratio：IHC: 1:200-1000 WB: 1:1000-5000 ICC/IF: 1:200-1000 ELISA: 1:5000-20000 IP: 1:50-200 Gene ID：1021 Synonyms：Cyclin-dependent kinase 6 Cell division protein kinase 6 Serine/threonine-protein kinase PLSTIRE Clonality：Monoclonal Conjugation：Non-conjugated Modification：Unmodified SwissProt ID：Q00534 IgG ARN-3236 \| Voclosporin \| Cetrorelix (Acetate) \| Abscisic acid \| Acivicin (hydrochloride) \| Pachymic acid \| β-Elemene \| Ticagrelor \| Galloylpaeoniflorin \| JH-RE-06 Trending products：Recombinant Proteins \| Bioactive Screening Libraries \| Natural Products \| Fluorescent Dye \| PROTAC \| Isotope-Labeled Compounds \| Oligonucleotides Brand introduction: &bull MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world； &bull More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas； &bull The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects； &bull Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services； &bull It has a professional experimental center and strict quality control and verification system； &bull Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products； &bull The biological activity of the products has been verified by the experiments of customers in various countries； &bull A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers； &bull Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world； &bull It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
Supplier Website	http://www.medchemexpress.com/antibody/cdk6-antibody-ya6286.html
Last Update	2025-10-14 16:03:33

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