2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics
  3. 11β-HSD AMPK
  4. 11β-HSD1-IN-25

11β-HSD1-IN-25 是一种选择性且口服有效的 11β-HSD1 抑制剂。 11β-HSD1-IN-25 能有效降低体外及血清中的糖皮质激素水平，并在体外和体内模型中减少脂质积累。11β-HSD1-IN-25 通过双重机制调节脂质代谢：抑制 11β-HSD1 以及激活 AMP 活化蛋白激酶 (AMPK) 信号通路。11β-HSD1-IN-25 可用于体内肥胖及相关代谢紊乱的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

11β-HSD1-IN-25

11β-HSD1-IN-25 Chemical Structure

CAS No. : 1261266-23-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

11β-HSD1-IN-25 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

11β-HSD1-IN-25 is a selective and orally active 11β-HSD1 inhibitor. 11β-HSD1-IN-25 effectively reduces glucocorticoid levels in vitro and serum, and diminishes lipid accumulation in both vitro and vivo. 11β-HSD1-IN-25 modulates lipid metabolism through dual mechanisms: inhibition of 11β-HSD1 and activation of the AMP-activated protein kinase (AMPK) signaling pathway. 11β-HSD1-IN-25 can be used for obesity and related metabolic disorders research[1].

体外研究
(In Vitro)

11β-HSD1-IN-25 (10 μM) 通过抑制 11β-HSD1 改善脂质代谢紊乱，并减少 3T3-L1 脂肪细胞中的脂质积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

11β-HSD1-IN-25 相关抗体:
体内研究
(In Vivo)

11β-HSD1-IN-25 (0.5 mg/kg，口服，每日一次，持续 60 天) 可减轻肥胖，减少脂肪组织中脂肪细胞的大小，并通过抑制 11β-HSD1 来改善脂肪组织的脂质代谢紊乱，改善 11β-HSD1 慢病毒诱导 (或不诱导) 的雄性 C57BL/6 小鼠的脂肪细胞肥大和炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 11β-HSD1 lentivirus induced (or not) (i.v.)-male C57BL/6 mice (8 weeks, 20-22 g)[1]
Dosage: 0.5 mg/kg
Administration: p.o., daily for 60 days
Result: Significantly mitigated weight gain when induced by 11β-HSD1 lentivirus.
Significantly reduced serum concentrations of corticosterone (CORT), cholesterol (CHO), triglycerides (TG), low-density lipoprotein (LDL), and high density lipoprotein (HDL).
Improved adipocyte morphology.
Decreased 11β-HSD1 protein expression.
Exhibited a substantial increase in the protein expression levels of UCP1, the p-AMPK/AMPK ratio, and CPT1 when reduced by 11β-HSD1 lentivirus when reduced by 11β-HSD1 lentivirus.
Showed a significant reduction in the mRNA expression of Hsd11b1, Srebp1c, Fas, and Acc1 and exhibited a increase in the expression levels of Cpt1, Ucp1, and Hsl when reduced by 11β-HSD1 lentivirus.
Not exhibited a significant elevation in FAS protein expression in adipose tissue when not reduced by 11β-HSD1 lentivirus.
Resulted in a substantial reduction in FAS protein expression.
Upregulated HSL protein no matter reduced by 11β-HSD1 lentivirus or not.
Significantly reduced F4/80 protein expression in adipose tissue.
分子量

432.31

Formula

C21H12F8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

11β-HSD1-IN-25 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

11β-HSD1-IN-251261266-23-211β-HSDAMPK11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenaseAMP-activated protein kinase11β-HSD1 inhibitorglucocorticoidlipid accumulationobesityInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
11β-HSD1-IN-25
目录号：
HY-180549
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z