2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 13-Hydroxy-alpha-tocopherol

13-Hydroxy-alpha-tocopherol 是一种具有抗氧化和抗增殖作用的脂溶性维生素 E 衍生物和抗癌剂。13-Hydroxy-alpha-tocopherol 能清除过氧自由基，并保护多不饱和脂肪酸免受氧化损伤。13-Hydroxy-alpha-tocopherol 不仅能抑制胶质瘤癌细胞生长，其缺乏还与复发性流产、胚胎发育迟缓及死亡密切相关。临床观察发现，13-Hydroxy-alpha-tocopherol 在复发性流产患者的卵泡液中的表达下调。13-Hydroxy-alpha-tocopherol 在复发性流产和胶质瘤的研究中具有重要的应用潜力。

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13-Hydroxy-alpha-tocopherol

13-Hydroxy-alpha-tocopherol Chemical Structure

CAS No. : 1160974-39-9

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13-Hydroxy-alpha-tocopherol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma[1][2].
体外研究
(In Vitro)

13-Hydroxy-alpha-tocopherol (Compound 7) (10 μM; 24 h) 可强效抑制小鼠胶质瘤 C6 细胞的增殖，使细胞数量降至未处理对照组的约 50%[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

13-Hydroxy-alpha-tocopherol 相关抗体:

Cell Proliferation Assay[2]

Cell Line: murine glioma C6 cancer cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Reduced cell proliferation to approximately 50% of the untreated control level.
分子量

446.71

Formula

C29H50O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

13-Hydroxy-alpha-tocopherol 相关分类

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Keywords:

13-Hydroxy-alpha-tocopherol1160974-39-9Endogenous Metaboliteglioma cancer cellsrecurrent spontaneous abortiongliomazebrafishfollicular fluidperoxyl radicalsin vitro fertilizationmurine glioma C6 cellsgene-knockout micepolyunsaturated fatty acidsInhibitorinhibitorinhibit

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