2. Protein Tyrosine Kinase/RTK Neuronal Signaling
  3. c-Met/HGFR Trk Receptor
  4. 1D228

1D228 是一种 c-Met/TRK 抑制剂，具有抗肿瘤活性。1D228 抑制细胞周期蛋白D1诱导G0/G1停滞并抑制癌细胞增殖和迁移。1D228 可用于胃、肝和血管肿瘤的研究。

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1D228

1D228 Chemical Structure

CAS No. : 2925447-16-9

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规格 价格 是否有货
1 mg ￥1600
询问价格 & 货期
5 mg ￥4000
询问价格 & 货期
10 mg 询价 询问价格 & 货期

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1D228 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

查看所有亚型
TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1D228 is a c-Met/TRK inhibitor with antitumor activity. 1D228 inhibits cyclin D1 to induce G0/G1 arrest and inhibit cancer cell proliferation and migration. 1D228 can be used in the study of gastric, liver and vascular tumors[1].

产品应用

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MHCC97H IC50
4.3 nM
Compound: 84; 1D228
Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 38733884]
MKN-45 IC50
1 nM
Compound: 84; 1D228
Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 38733884]
分子量

507.60

Formula

C30H29DN6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1D228 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1D2282925447-16-9c-Met/HGFRTrk ReceptorTropomyosin related kinase receptorc-Met/TRK inhibitorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-157148
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