2. Others Neuronal Signaling
  3. Drug Derivative Beta-secretase Amyloid-β
  4. 2,2′,4,4′-Tetrahydroxychalcone

2,2′,4,4′-Tetrahydroxychalcone (Compound 18) 是一种选择性强且有效的 BACE1 抑制剂，其 IC50 值为 0.62 μM。2,2′,4,4′-Tetrahydroxychalcone 是 Isoliquiritigenin (HY-N0102) 的衍生物，被发现存在于甘草 (Glycyrrhiza uralensis) 中。2,2′,4,4′-Tetrahydroxychalcone 能够阻断淀粉样前体蛋白 (APP) 的 β 切割步骤，从而减少 β-淀粉样蛋白 (Aβ) 肽的产生。2,2′,4,4′-Tetrahydroxychalcone 可用于阿尔茨海默病的研究。

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2,2′,4,4′-Tetrahydroxychalcone

2,2′,4,4′-Tetrahydroxychalcone Chemical Structure

CAS No. : 123702-96-5

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2,2′,4,4′-Tetrahydroxychalcone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2,2′,4,4′-Tetrahydroxychalcone (Compound 18) is a selective and potent BACE1 inhibitor with an IC50 of 0.62 μM. 2,2′,4,4′-Tetrahydroxychalcone is a derivative of Isoliquiritigenin (HY-N0102) found in Glycyrrhiza uralensis. 2,2′,4,4′-Tetrahydroxychalcone can block the β-cutting step of amyloid precursor protein (APP), thereby reducing the production of β-amyloid (Aβ) peptide. 2,2′,4,4′-Tetrahydroxychalcone can be used for research of Alzheimer’s disease[1].

IC50 & Target[1]

BACE1

0.62 μM (IC50)

分子量

272.25

Formula

C15H12O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2,2′,4,4′-Tetrahydroxychalcone 相关分类

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Keywords:

2,2′,4,4′-Tetrahydroxychalcone123702-96-5Drug DerivativeBeta-secretaseAmyloid-βDrug derivativeBACEβ-Secretase β-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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