2. Apoptosis
  3. Apoptosis
  4. 2-Deoxy-L-ribose

2-Deoxy-L-ribose  (Synonyms: 2-脱氧-L-核糖)

目录号: HY-W012670
产品使用指南 技术支持

2-Deoxy-L-ribose 是 2-Deoxy-d-ribose 的立体异构体，可抑制 2-Deoxy-d-ribose 的抗凋亡作用。2-Deoxy-L-ribose 可抑制过表达胸苷磷酸化酶的肿瘤细胞转移。

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2-Deoxy-L-ribose

2-Deoxy-L-ribose Chemical Structure

CAS No. : 18546-37-7

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规格 价格 是否有货 数量
100 mg ￥100
1 - 2 周
250 mg ￥168
1 - 2 周
1 g ￥338
1 - 2 周
5 g ￥842
1 - 2 周
10 g ￥1350
1 - 2 周
50 g   询价  

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Customer Review

2-Deoxy-L-ribose 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase[1].

体外研究
(In Vitro)

2-Deoxy-L-ribose（10-100 μM；24 小时）显著减少缺氧条件下侵袭 KB/TP 细胞的数量[1]。
2-Deoxy-L-ribose（10-100 μM；48 小时）降低缺氧条件下 KB/TP 细胞中的 VEGF 和 IL-8 mRNA 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Deoxy-L-ribose 相关抗体:

Cell Invasion Assay[1]

Cell Line: KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
Concentration: 10 μM or 100 μM
Incubation Time: 24 hours
Result: Inhibited TP-overexpressing tumor cell invasion in vitro.

RT-PCR[1]

Cell Line: KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
Concentration: 10 μM or 100 μM
Incubation Time: 48 hours
Result:
体内研究
(In Vivo)

2-Deoxy-L-ribose（20-100 mg/kg；口服；每日；28 天）可减少肝转移结节和转移面积，抑制血管生成，促进细胞凋亡[1]。
2-Deoxy-L-ribose（20 mg/kg；口服；每日；52 天）在减少腹部转移结节方面比 Tegafur (HY-17400) (100 mg/kg) 效果更佳[1]。
。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice intrasplenically injected with KB/TP cells[1]
Dosage: 20 mg/kg/day or 100 mg/kg/day
Administration: Oral (p.o.), daily for 28 days
Result: Effectively inhibited TP-mediated liver metastasis and angiogenesis.
Animal Model: BALB/c nude mice with subcutaneous KB/TP cell injection[1]
Dosage: 20 mg/kg/day
Administration: Oral (p.o.), daily until day 52
Result: Decreased the number of metastatic nodules in organs.
分子量

134.13

Formula

C5H10O4
CAS 号
中文名称

2-脱氧-L-核糖
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Deoxy-L-ribose 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Deoxy-L-ribose18546-37-72-脱氧-L-核糖ApoptosisInhibitorinhibitorinhibit

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