2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. 2-Methyl-2-butenyl (E)-Caffeate

2-Methyl-2-butenyl (E)-Caffeate 是一种咖啡酸酯类化合物。2-Methyl-2-butenyl (E)-Caffeate 所在的石油醚和氯仿提取物对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 有抑制作用。2-Methyl-2-butenyl (E)-Caffeate 所在的乙醚提取物表现出强抗氧化能力。2-Methyl-2-butenyl (E)-Caffeate 可用于研究阿尔茨海默病。

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2-Methyl-2-butenyl (E)-Caffeate

2-Methyl-2-butenyl (E)-Caffeate Chemical Structure

CAS No. : 118971-61-2

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2-Methyl-2-butenyl (E)-Caffeate 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Methyl-2-butenyl (E)-Caffeate is a type of caffeic acid ester compound. The petroleum ether and chloroform extracts containing 2-Methyl-2-butenyl (E)-Caffeate have inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The ether extract containing 2-Methyl-2-butenyl (E)-Caffeate exhibits strong antioxidant properties. 2-Methyl-2-butenyl (E)-Caffeate can be used in the research of Alzheimer's disease[1].

IC50 & Target[1]

AChE

 

BChE

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 EC50
0.578 μM
Compound: 20, prenyl caffeate
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay
[PMID: 18667320]
RAW264.7 EC50
30 μM
Compound: 20, prenyl caffeate
Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay
[PMID: 18667320]
分子量

248.27

Formula

C14H16O4
CAS 号
结构分类
初始来源

Algerian propolis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Methyl-2-butenyl (E)-Caffeate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

2-Methyl-2-butenyl (E)-Caffeate118971-61-2Cholinesterase (ChE)Algerian propolischemical compositionantioxidant activityanticholinesterase activityphenolic compoundsflavonoidsacetylcholinesterase inhibitionnatural productsPopulus spp.Citrus sppInhibitorinhibitorinhibit

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