2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. 2-Methyl-5-acetylphenol

2-Methyl-5-acetylphenol 是一种羟基化甲基苯乙酮，存在于 Cannabis sativa subsp. sativa 的地上部分。2-Methyl-5-acetylphenol 与 HIPK2 具有良好的结合能力。2-Methyl-5-acetylphenol 无法逆转 MPP+ (1-methyl-4-phenyl-pyridinium ion) 诱导的神经元细胞毒性。2-Methyl-5-acetylphenol 可用于研究帕金森病[1]。

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2-Methyl-5-acetylphenol

2-Methyl-5-acetylphenol Chemical Structure

CAS No. : 33414-49-2

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2-Methyl-5-acetylphenol 相关抗体

Top Publications Citing Use of Products

查看 DYRK 亚型特异性产品:

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Methyl-5-acetylphenol is a hydroxylated methylacetophenone that exists in the aerial parts of Cannabis sativa subsp. sativa. 2-Methyl-5-acetylphenol exhibits strong binding affinity to HIPK2. 2-Methyl-5-acetylphenol cannot reverse MPP+ (1-methyl-4-phenyl-pyridinium ion)-induced neuronal cytotoxicity. 2-Methyl-5-acetylphenol can be used for Parkinson's disease research[1].

IC50 & Target[1]

HIPK2

 

体外研究
(In Vitro)

2-Methyl-5-acetylphenol (Compound 9) (12.5-100 μM；作用 24 h) 在 12.5-100 μM 浓度下无法逆转 MPP+诱导的 SH-SY5Y 细胞毒性，反而加剧其毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Methyl-5-acetylphenol 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 12.5, 25, 50, 100 μM
Incubation Time: 24 h
Result: Recorded cell viability of 97.83%, 99.78%, 98.17%, and 96.25% when applied alone at 12.5, 25, 50, and 100 μM, respectively.
Detected cell viability of 33.75%, 38.41%, 38.98%, and 39.27% when applied in combination with 1.8 mM MPP⁺ at 12.5, 25, 50, and 100 μM, respectively.
Calculated rescue effect of -24.29%, -13.84%, -12.56%, and -11.91% at 12.5, 25, 50, and 100 μM, respectively.
分子量

150.17

Formula

C9H10O2
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

2-Methyl-5-acetylphenol 相关分类

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Keywords:

2-Methyl-5-acetylphenol33414-49-2DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseSH-SY5Y cellsMPP+HIPK2neuronal cellsCannabis sativa subsp. sativaATP-binding pocketInhibitorinhibitorinhibit

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