2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. Endogenous Metabolite Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. 2-Phosphoglyceric acid

2-Phosphoglyceric acid  (Synonyms: DL-2-phosphoglyceric acid)

目录号: HY-113167
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2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) 是一种糖酵解底物，被烯醇化酶催化生成磷酸烯醇丙酮酸酯 (PEP)。2-Phosphoglyceric acid 通过下调 ACSL4、上调 GPX4，从而抑制铁死亡 (ferroptosis) 通路，具有显著的神经保护作用。2-Phosphoglyceric acid 反映了细胞整体的代谢状态和通量。

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2-Phosphoglyceric acid

2-Phosphoglyceric acid Chemical Structure

CAS No. : 2553-59-5

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2-Phosphoglyceric acid 相关抗体

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GPX1 GPX4

  • 生物活性

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  • 参考文献

生物活性

2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

2-Phosphoglyceric acid 在乳酸乳球菌糖酵解的稳定期显著升高，是细胞从高速生长、活跃糖酵解状态转向生长停滞或缓慢状态的代谢标志[1]。
2-Phosphoglyceric acid (50-200 μM) 在氧糖剥夺/再灌注 (OGD/R) 诱导的小鼠海马神经元细胞 (HT-22) 损伤模型中，其含量显著下调。外源性补充后能有效减轻 OGD/R 引起的神经元死亡[2]。
2-Phosphoglyceric acid (100-200 μM) 降低 HT-22 细胞内 Fe2+ 积累和 ROS 水平，改善线粒体功能，下调 ACSL4 并上调 GPX4 蛋白的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Phosphoglyceric acid 相关抗体:
体内研究
(In Vivo)

2-Phosphoglyceric acid (100-200 μM，侧脑室注射 (i.c.v.)，单次给药) 能有效减轻新生大鼠缺氧缺血性脑损伤导致的脑组织损伤和神经元丢失[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypoxic-ischemic brain damage (HIBD) model established in neonatal rats[2]
Dosage: 100 and 200 μM
Administration: Intraventricular injection (i.c.v), single dose
Result: Significantly reduced the volume of cerebral infarction.
Significantly increased the number of surviving neurons in the cortex and hippocampus, and reduced neuronal damage.
分子量

186.06

Formula

C3H7O7P
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Phosphoglyceric acid 相关分类

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Keywords:

2-Phosphoglyceric acid2553-59-5DL-2-phosphoglyceric acidEndogenous MetaboliteFerroptosisGlutathione PeroxidaseReactive Oxygen Species (ROS)Hypoxic-ischemic brain damage (HIBD)Oxygen-glucose deprivation/reoxygenation (OGD/R)NeuroprotectionACSL4/GPX4 axisInhibitorinhibitorinhibit

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