2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor Drug Metabolite
  4. 20β-Dihydrocortisol

20β-Dihydrocortisol (20β-DHF) 是 Hydrocortisone (Cortisol) (HY-N0583) 的代谢产物。20β-Dihydrocortisol 是糖皮质激素受体 (GR) 的弱内源性激动剂。20β-Dihydrocortisol 可通过 CBR1 催化由氢化可的松转化而来，该过程依赖于 NADPH。20β-Dihydrocortisol 可用​​于肥胖症的研究。

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20β-Dihydrocortisol

20β-Dihydrocortisol Chemical Structure

CAS No. : 116-58-5

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规格 价格 是否有货 数量
5 mg ￥1500
5 - 6 周
10 mg ￥2500
5 - 6 周
25 mg ￥4850
5 - 6 周
50 mg   询价  
100 mg   询价  

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Other Forms of 20β-Dihydrocortisol:

20β-Dihydrocortisol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity[1].

体内研究
(In Vivo)

在饮食诱导的肥胖小鼠模型中，通过药理学方法抑制 CBR1 会导致更明显的葡萄糖耐受不良，并伴有肝脏糖皮质激素受体 (GR) 信号增强的证据。这些发现表明，CBR1 生成 20β-Dihydrocortisol 是调节 GR 激活的新途径，并能提供酶促保护，防止肥胖症中 GR 过度激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

364.48

Formula

C21H32O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

20β-Dihydrocortisol 相关分类

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Keywords:

20β-Dihydrocortisol116-58-520β-DHFGlucocorticoid ReceptorDrug MetaboliteMetabolite of Hydrocortisoneglucocorticoid receptorNADPHCBR1obesityInhibitorinhibitorinhibit

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