2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 3-Phenylthiophene

3-Phenylthiophene (Compound 25) 是一种 CYP2A6 抑制剂，其 Ki 为 3.3 μM。3-Phenylthiophene 对 CYP2E1、CYP2B6、CYP2C9、CYP2C19 的 Ki 分别为 9.7、14、112 和 107 μM，对 CYP3A4 和 CYP2D6 无显著抑制。3-Phenylthiophene 可用于戒烟研究。

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3-Phenylthiophene

3-Phenylthiophene Chemical Structure

CAS No. : 2404-87-7

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规格 价格 是否有货 数量
100 mg ￥150
In-stock
250 mg ￥270
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500 mg ￥390
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1 g ￥630
In-stock
5 g ￥2220
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3-Phenylthiophene 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

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  • 参考文献

生物活性

3-Phenylthiophene (Compound 25) is a CYP2A6 inhibitor with a Ki value of 3.3 μM. The Ki values for CYP2E1, CYP2B6, CYP2C9, and CYP2C19 are 9.7, 14, 112, and 107 μM respectively. It shows no significant inhibition on CYP3A4 and CYP2D6. 3-Phenylthiophene can be used in smoking cessation research[1].

IC50 & Target[1]

CYP2A6

3.3 μM (Ki)

CYP2E1

9.7 μM (Ki)

CYP2B6

14 μM (Ki)

CYP2C9

112 μM (Ki)

CYP2C19

107 μM (Ki)

CYP3A4

> 400 μM (Ki)

CYP2D6

> 400 μM (Ki)

分子量

160.23

Formula

C10H8S
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

3-Phenylthiophene 相关分类

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Keywords:

3-Phenylthiophene2404-87-7Cytochrome P450CYPsenzyme inhibitorstructure-activity relationshipkineticsselectivitymechanism-based inactivationcocrystallizationnicotine analoguesInhibitorinhibitorinhibit

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