2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism
  4. (3S,4R)-ME-344

(3S,4R)-ME-344 是 ME-344 (HY-112749) 的 (3S,4R)-对映异构体。ME-344 是一种线粒体血红素加氧酶 1 (HO-1) 抑制剂。ME-344 特异性结合并改变 HO-1 的结构，并增加 HO-1 从粗面内质网向线粒体的转位，但仅限于药物敏感细胞 (如 H460 和 SHP-77 细胞)。ME-344 会降低线粒体 ATP 的产生，并诱导 ROS，随后破坏氧化还原稳态和线粒体功能。ME-344 具有显著的抗肿瘤活性，可用于乳腺癌等癌症的研究。

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(3S,4R)-ME-344

(3S,4R)-ME-344 Chemical Structure

CAS No. : 1374524-84-1

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(3S,4R)-ME-344 相关抗体

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HO-1 HO-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 (HY-112749). ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research[1].

分子量

348.39

Formula

C22H20O4
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

(3S,4R)-ME-344 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3S,4R)-ME-3441374524-84-1Heme Oxygenase (HO)Reactive Oxygen Species (ROS)Mitochondrial MetabolismHeme Oxygenase(3S,4R)-enantiomerHO-1InhibitorROSATPRedox homeostasisMitochondrial functionAntitumorH460 cellsSHP-77 cellsBreast cancerinhibitorinhibit

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目录号：
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