2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. 4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride 

目录号: HY-107560 纯度: 99.35%
COA 产品使用指南 技术支持

4-Methylhistamine hydrochloride 是 4-Methylhistamine (HY-W580721) 的二盐酸盐。4-Methylhistamine 是一种强效且选择性的组胺 4 受体 (H4R) 激动剂，其 Ki 值为 50 nM。4-Methylhistamine 对 hH4R 的选择性比对其他组胺受体亚型高 100 倍以上。4-Methylhistamine 能强效激活人 H4R (pEC50 值为 7.4)。4-Methylhistamine 可用于癌症、炎症和免疫学方面的研究，如肺癌和皮肤炎症。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride Chemical Structure

CAS No. : 36376-47-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥1000
In-stock
10 mg ￥1600
In-stock
25 mg ￥3200
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of 4-Methylhistamine dihydrochloride:

4-Methylhistamine dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-Methylhistamine hydrochloride is the dihydrochloride salt of 4-Methylhistamine (HY-W580721). 4-Methylhistamine is a potent and selective agonist of histamine 4 receptor (H4R) with a Ki of 50 nM. 4-Methylhistamine has a >100-fold selectivity for the hH4R over the other histamine receptor subtypes. 4-Methylhistamine can potently activate the hH4R (pEC50 = 7.4). 4-Methylhistamine can be used for the researches of cancer, inflammation and immunology, such as lung cancer and skin inflammation[1][2][3][4].

IC50 & Target

H4 receptor

 

体外研究
(In Vitro)

4-Methylhistamine (1-10 μM, 12 h) 可抑制 A549、H157、H460 和 H322 细胞的增殖[4]。
4-Methylhistamine (1 μM, 12 h) 会降低 A549 细胞中 TGF-β1 mRNA 的表达[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-Methylhistamine dihydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: A549, H157, H460 and H322 cells
Concentration: 1 μM
Incubation Time: 12 h
Result: Increased E-cadherin levels and decreased Vimentin levels.
体内研究
(In Vivo)

4-Methylhistamine (30 mg/kg，腹腔注射，在应激前 2 天开始每天两次) 可调节慢性应激对 Balb/c 小鼠 Th1/Th2 细胞因子平衡的影响[2]。
4-Methylhistamine (20-40 mg/kg，腹腔注射，连续 10 天每天一次) 可减轻 Imiquimod (HY-B0180) 诱导的小鼠银屑病样皮肤炎症[3]。
4-Methylhistamine (100 μmol/kg，静脉注射，每两天一次，持续 33 天) 可减小 A549 肿瘤小鼠的平均肿瘤体积并延长其生存期[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice with chronic restraint[2]
Dosage: 30 mg/kg
Administration: Intraperitoneally injection, twice a day before 2 days prior to stress
Result: Increase in the CD4+ T cells as well as in IFN-γ production.
Decreased IL-4 expression.
Upregulated expression of IL-1β, IFN-γ and TNF-α mRNA.
Animal Model: Imiquimod (HY-B0180)-induced psoriasis-like dermatitis mice[3]
Dosage: 20 and 40 mg/kg
Administration: Intraperitoneally injection, once a day for 10 days
Result: Ameliorated the total clinical severity scores.
Attenuated the psoriatic phenotypes, including epidermal hyperplasis, hyperkeratosis and lymphocytes infiltration.
Led to reductions in the levels of Th1 cytokines (TNF-a, IFN-a, and IL-27).
Increased CD4+CD25+FoxP3+ regulatory T (Treg) cells.
Animal Model: A549 tumor mice[4]
Dosage: 100 μmol/kg
Administration: Intravenously injection, every other day for 33 days
Result: Decreased tumor volume and the proliferation of tumour cells.
Prolonged survival of mice.
Increased the mRNA expression of E-cadherin and decreased Vimentin levels.
分子量

198.10

Formula

C6H13Cl2N3
CAS 号
性状

固体

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (631.00 mM; 超声助溶)

DMSO 中的溶解度 : 20 mg/mL (100.96 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.0480 mL 25.2402 mL 50.4803 mL
5 mM 1.0096 mL 5.0480 mL 10.0961 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.35%

COA (289 KB) HNMR (231 KB) LCMS (87 KB)

产品使用指南 (1538 KB)
参考文献

4-Methylhistamine dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.0480 mL 25.2402 mL 50.4803 mL 126.2008 mL
5 mM 1.0096 mL 5.0480 mL 10.0961 mL 25.2402 mL
10 mM 0.5048 mL 2.5240 mL 5.0480 mL 12.6201 mL
15 mM 0.3365 mL 1.6827 mL 3.3654 mL 8.4134 mL
20 mM 0.2524 mL 1.2620 mL 2.5240 mL 6.3100 mL
25 mM 0.2019 mL 1.0096 mL 2.0192 mL 5.0480 mL
30 mM 0.1683 mL 0.8413 mL 1.6827 mL 4.2067 mL
40 mM 0.1262 mL 0.6310 mL 1.2620 mL 3.1550 mL
50 mM 0.1010 mL 0.5048 mL 1.0096 mL 2.5240 mL
60 mM 0.0841 mL 0.4207 mL 0.8413 mL 2.1033 mL
80 mM 0.0631 mL 0.3155 mL 0.6310 mL 1.5775 mL
100 mM 0.0505 mL 0.2524 mL 0.5048 mL 1.2620 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Methylhistamine36376-47-3Histamine ReceptorHistamine 4 receptorH4RA549lung cancerSkin inflammationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
4-Methylhistamine dihydrochloride
目录号：
HY-107560
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

nceSelect() == '湖南省'}">湖南省
  • 海南省
  • 山东省
  • 浙江省
  • 江苏省
  • 吉林省
  • 福建省
  • 河北省

    • A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z