2. Immunology/Inflammation
  3. Interleukin Related
  4. 4L2-P13D

4L2-P13D 是一种 IL-11 拮抗剂，IC50 为 2.8 μM。4L2-P13D 对 hIL-11 的 KD 为 11 nM。4L2-P13D 具有抗纤维化和肾脏保护活性。4L2-P13D 可用于肾纤维化的研究。

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4L2-P13D

4L2-P13D Chemical Structure

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4L2-P13D 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4L2-P13D is an IL-11 antagonist with an IC50 of 2.8 μM. 4L2-P13D has a KD of 11 nM for hIL-11. 4L2-P13D exhibits antifibrotic and renoprotective activities. 4L2-P13D can be used in the research of renal fibrosis[1].

体外研究
(In Vitro)

4L2-P13D (0.5-5 μM；72 h) 可剂量依赖性地降低 TGF-β1 诱导的 HK-2 细胞中促纤维化因子 (FN1、COL1A1) 的表达[1]。
4L2-P13D (0-50 μM；24 h) 在浓度高达 50 μM 时对 HK-2 细胞无细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4L2-P13D 相关抗体:

Western Blot Analysis[1]

Cell Line: TGF-β1-induced human proximal tubular epithelial (HK-2) cells
Concentration: 0.5, 2 and 5 μM
Incubation Time: 72 h
Result: Dose-dependently reduced fibronectin (FN1) and type I collagen (COL1A1) expression.
体内研究
(In Vivo)

4L2-P13D (0.5-2 mg/kg; s.c.; 每日给药；7 天) 在 UUO 小鼠模型中展现出强效的抗肾纤维化活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 6-8 weeks old, UUO model)[1]
Dosage: 0.5 mg/kg; 2 mg/kg
Administration: s.c.; daily; 7 days
Result: Significantly reduced expression levels of fibrosis markers FN1 and α-smooth muscle α-SMA.
Remarkably reduced proinflammatory markers (TNF-α, TGF-β1, IL-6, IL-1β) and kidney injury markers (Kim1, Ngal).
Reduced blood urea nitrogen (BUN) and creatinine levels.
Significantly improved collagen deposition, with the high-dose group showing superior efficacy compared to the low-dose group.
分子量

1859.11

Formula

C89H123N19O23S
Sequence

Ac-Tyr-Leu-Ile-Gln-His-Tyr-Tyr-Thr-Phe-Ile-Ala-Leu-Asp-Cys-Gly-NH2 (sulfide bridge: Tyr1-Cys14)
Sequence Shortening

Ac-YLIQHYYTFIALDCG-NH2 (sulfide bridge: Tyr1-Cys14)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4L2-P13D 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4L2-P13DInterleukin RelatedILrenal epithelial cellsHK-2 cellsunilateral ureteral obstruction mouse modelsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P11623
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