2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Adrenergic Receptor
  4. 5,7-Dihydroxytryptamine hydrobromide

5,7-Dihydroxytryptamine hydrobromide  (Synonyms: 5,7-DHP hydrobromide)

目录号: HY-N18471A
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5,7-Dihydroxytryptamine (5,7-DHT) hydrobromide 是一种神经毒素，选择性损伤大脑中的血清素能 (5-HT) 和去甲肾上腺素能 (NE) 神经元。5,7-Dihydroxytryptamine hydrobromide 作为自体荧光的血清素衍生物，可与这些神经元的高亲和力转运体结合并被选择性摄取，随后在细胞内代谢产生活性氧自由基，导致轴突末梢退行性变和神经化学物质耗竭。5,7-Dihydroxytryptamine hydrobromide 可用于神经科学研究。

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5,7-Dihydroxytryptamine hydrobromide

5,7-Dihydroxytryptamine hydrobromide Chemical Structure

CAS No. : 1841081-30-8

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5,7-Dihydroxytryptamine hydrobromide 相关抗体

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  • 生物活性

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生物活性

5,7-Dihydroxytryptamine (5,7-DHT) hydrobromide is a neurotoxin that selectively damages serotonergic (5-HT) and noradrenergic (NE) neurons in the brain. 5,7-Dihydroxytryptamine hydrobromide, as an autofluorescent serotonin derivative, binds to the high-affinity transporters of these neurons and is selectively taken up, followed by intracellular metabolism to generate reactive oxygen species, which causes axonal terminal degeneration and neurochemical depletion. 5,7-Dihydroxytryptamine hydrobromide is applicable to neuroscience research[1][2][3][4].

体外研究
(In Vitro)

5,7-Dihydroxytryptamine (25 μM；60 min) hydrobromide 可特异性标记 14 日龄 Wistar 大鼠胎鼠原代中脑培养物中的 5-羟色胺能细胞 (而非酪氨酸羟化酶免疫反应阳性的多巴胺能细胞)[3]。
5,7-Dihydroxytryptamine (20 nM；15 min) hydrobromide 对上行 5-HT 通路的损伤会降低大鼠大脑皮层和下丘脑切片中 3H-5-HT 的体外摄取量，但不会显著改变3H-NA 的摄取量[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5,7-Dihydroxytryptamine hydrobromide 相关抗体:
体内研究
(In Vivo)

5,7-Dihydroxytryptamine (8 μg；双侧立体定位输注至伏隔核；2 分钟) hydrobromide 可在 Wistar 大鼠中诱导类似听觉过敏的行为，表现为无背景噪声环境下的听觉惊跳反射振幅显著升高[1]。
5,7-Dihydroxytryptamine (12.5-50 μg; i.c.v.) hydrobromide 可在 C57BL/6 小鼠中引起海马去甲肾上腺素和 5-羟色胺的剂量依赖性耗竭[2]。
5,7-Dihydroxytryptamine (每个注射位点 4 µg，立体定位注射；速率 1 µL/min) hydrobromide 可对上行 5-HT 通路产生选择性化学损伤，该损伤会降低皮质和下丘脑终末区域的 3H-5-HT 摄取量 (对 3H-NA 摄取无显著影响)、诱发小鼠杀戮行为、增加电击诱导的拳击姿态、降低对感觉刺激的习惯化速率，且对饲养笼内活动无显著改变[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult male, 175-200 g at surgery)[1]
Dosage: 8 μg
Administration: bilateral stereotaxic infusion into nucleus accumbens; over 2 min, injector left in place for 1 additional min post-infusion
Result: Increased mean amplitude of the acoustic startle reflex significantly across all stimulus intensities in the absence of background noise compared to the Sham-lesion group.
Showed no significant differences in startle amplitude between the DHT-lesion, Sham-lesion, and intact groups at any stimulus intensity in the presence of background noise.
Confirmed nearly complete loss of serotonergic neurons in the nucleus accumbens via immunohistochemistry.
Animal Model: C57BL/6 (male, 2 and 10 months old, 20-30 g)[2]
Dosage: 12.5 μg; 25 μg; 50 μg
Administration: i.c.v.; single dose
Result: Had a damaging effect on the noradrenergic system, and this effect was independent of the age of the mice.
Exerted stronger toxic effects on serotonergic neurons in young individuals.
Animal Model: M/511-Wistar (male, 240-280 g)[4]
Dosage: 4 µg (calculated as the base) per injection site
Administration: stereotactic injection; 1 µl/min rate; needle left in situ for 1 min post-injection
Result: Reduced ³H-5-HT uptake but did not change ³H-NA uptake in the cortex (medial bundle lesion group).
Reduced ³H-NA uptake to 75% of control (non-significant) in the cortex (medial plus lateral bundle lesion group).
Induced mouse killing behavior in 4 of 8 rats (medial bundle lesion group) and 6 of 7 rats (medial plus lateral bundle lesion group).
Required significantly more trials to reach habituation criterion for touch (both lesion groups).
Required significantly more trials for acoustic stimulation habituation (only medial plus lateral lesion group).
Showed a significantly higher number of boxing positions in the shock elicited fighting test (both lesion groups).
Showed no significant changes in home cage activity (both lesion groups).
分子量

273.13

Formula

C10H13BrN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5,7-Dihydroxytryptamine hydrobromide 相关分类

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Keywords:

5,7-Dihydroxytryptamine1841081-30-85,7-DHP5-HT ReceptorAdrenergic ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptornoradrenergic neurotoxicityserotonin transporterparkinson's diseaseserotoninMAO Ahyperacusisserotonergic neuronsalzheimer's diseaseratsmiceInhibitorinhibitorinhibit

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