2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor Serotonin Transporter
  4. 5-HT2A receptor agonist-13

5-HT2A receptor agonist-13 (Compound 28c) 是一种能透过血脑屏障的 5-HT2A 受体 (5-HT2A receptor) 部分激动剂，其 EC50 值为 416.9 nM，Ki 值为 113.9 nM。5-HT2A receptor agonist-13 对 5-HT2B 受体 (5-HT2B receptor) (EC₅₀ = 120.2 nM)、D2 受体 (D2 receptor) (Ki = 1298 nM) 具有非常弱的激动活性，对 5-HT2C 受体没有活性。5-HT2A receptor agonist-13 对血清素转运体 (SERT) 的抑制活性很弱 (EC₅₀ = 977.2 nM)。5-HT2A receptor agonist-13 在小鼠模型中具有抗抑郁活性，且不会诱发致幻行为。5-HT2A receptor agonist-13 可用于研究重度抑郁症 (MDD) 和难治性抑郁症 (TRD)。

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5-HT2A receptor agonist-13

5-HT2A receptor agonist-13 Chemical Structure

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5-HT2A receptor agonist-13 相关抗体

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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  • 生物活性

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生物活性

5-HT2A receptor agonist-13 (Compound 28c) is a partial agonist of the 5-HT2A receptor, with an EC50 value of 416.9 nM and a Ki value of 113.9 nM. 5-HT2A receptor agonist-13 exhibits very weak agonistic activity towards the 5-HT2B receptor (EC50 = 120.2 nM), D2 receptor (Ki = 1298 nM), and has no activity towards the 5-HT2C receptor. 5-HT2A receptor agonist-13 exhibits weak inhibitory activity on the serotonin transporter (SERT) (EC50 = 977.2 nM). 5-HT2A receptor agonist-13 has antidepressant activity in mouse models and does not induce hallucinogenic behavior. 5-HT2A receptor agonist-13 can be used for the study of major depressive disorder (MDD) and treatment-resistant depression (TRD)[1].
IC50 & Target[1]

5-HT2A Receptor

113.9 nM (Ki)

5-HT2B Receptor

120.2 nM (EC50)

D2 Receptor

1298 nM (Ki)

分子量

333.43

Formula

C21H23N3O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-HT2A receptor agonist-13 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-HT2A receptor agonist-135-HT ReceptorDopamine ReceptorSerotonin TransporterSerotonin Receptor5-hydroxytryptamine Receptor5-HTTSERTSLC6A45-HT2A receptor partial agonistsnon-hallucinogenic psychedelic analogsantidepressant activityInhibitorinhibitorinhibit

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