2. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. NF-κB NO Synthase Reactive Oxygen Species (ROS)
  4. 8-Deoxylactucin

8-Deoxylactucin 是一种具有口服活性的倍半萜内酯。8-Deoxylactucin 抑制 LPS (HY-D1056) 诱导的 RAW264.7 巨噬细胞中 NO 的产生，其 IC50 值为 4.35 μM。8-Deoxylactucin 通过阻断 NF-κB 通路发挥抗炎作用。8-Deoxylactucin 在 LPS/D-半乳糖胺诱导的小鼠急性肝炎模型中显示出肝保护疗效。8-Deoxylactucin 可用于炎症性疾病和炎症性肝损伤的研究。

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8-Deoxylactucin

8-Deoxylactucin Chemical Structure

CAS No. : 65725-10-2

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规格 价格 是否有货 数量
1 mg ￥3360
1 - 2 周
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8-Deoxylactucin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages with an IC50 value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries[1].

体外研究
(In Vitro)

8-Deoxylactucin (1 h 预处理) 显著抑制 LPS (HY-D1056) 诱导的 RAW264.7 巨噬细胞中 NO 产生，其 IC50 值为 4.35 μM[1]。
8-Deoxylactucin (1-10 μM, 1 h 预处理) 显著降低 LPS 诱导的 RAW264.7 细胞中 iNOS 的 mRNA 和蛋白表达，以及促炎症细胞因子包括 IL-1β、IL-6 和 TNF-α 的 mRNA 表达[1]。
8-Deoxylactucin (1-10 μM, 2 h 预处理) 显著阻断 LPS 诱导的 RAW264.7 巨噬细胞中 IKKα/β 和 IκBα 的磷酸化，抑制 IκBα 降解，并减少 NF-κB p65 的核积累[1]。
8-Deoxylactucin (1-10 μM, 1 h 预处理) 显著增强 RAW264.7 细胞中 NRF2 的蛋白表达和核转位，上调 NRF2 靶向抗氧化基因 (HO, NQO1) 的蛋白表达，并减少 ROS 产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-Deoxylactucin 相关抗体:

Real Time qPCR[1]

Cell Line: RAW264.7 macrophages
Concentration: 1, 5, 10 μM
Incubation Time: 1, 2 h pretreatment
Result: Reduced the mRNA expression of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α in RAW264.7 cells.

Western Blot Analysis[1]

Cell Line: RAW264.7 macrophages
Concentration: 1, 5, 10 μM
Incubation Time: 1, 2 h pretreatment
Result: Reduced LPS-induced expression of iNOS.
Blocked LPS-induced phosphorylation of IKKα/β and IκBα.
Inhibited IκBα degradation.
Reduced nuclear accumulation of NF-κB p65.
体内研究
(In Vivo)

8-Deoxylactucin (2-10 mg/kg，灌胃给药，每日一次，连续 5 天) 显著降低 LPS/D-半乳糖胺 (D-GalN) 诱导的小鼠肝指数增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS/D-galactosamine (D-GalN) (LPS: 50 μg/kg, D-GalN: 700 mg/kg, i.p. injection) was administered to 6-week-old male ICR mice (22-24 g) to induce acute hepatitis model[1]
Dosage: 2, 5, 10 mg/kg
Administration: i.g., once daily, 5 days
Result: Achieved significant reduction in liver index.
Showed significant alleviation of liver tissue damage and decreased pathological scores.
Reduced serum ALT and AST levels.
Decreased protein expression of IL-1β, IL-6, TNF-α, and 4-HNE in liver tissues.
分子量

260.29

Formula

C15H16O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

8-Deoxylactucin 相关分类

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Keywords:

8-Deoxylactucin65725-10-2NF-κBNO SynthaseReactive Oxygen Species (ROS)Nuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSCichorium intybusinflammatory diseasesNORAW264.7NF-κB pathwayInhibitorinhibitorinhibit

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