2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. 9β,10β-epoxy Hexahydrocannabinol

9β,10β-epoxy Hexahydrocannabinol  (Synonyms: 9β,10β-EHHC; 9β,10β-epoxy HHC)

目录号: HY-179436
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9β,10β-epoxy Hexahydrocannabinol 是一种大麻素受体 1 (CB1) 和 CB2 受体配体，对 CB1 的结合亲和力为 224 nM，对 CB2 的结合亲和力为 335 nM。9β,10β-epoxy Hexahydrocannabinol 可降低小鼠的自发活动能力、诱导僵住症、降低体温并产生镇痛作用。9β,10β-epoxy Hexahydrocannabinol 可用于神经系统疾病的研究。

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9β,10β-epoxy Hexahydrocannabinol

9β,10β-epoxy Hexahydrocannabinol Chemical Structure

CAS No. : 1781270-07-2

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9β,10β-epoxy Hexahydrocannabinol 相关抗体

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CB1 CB2

  • 生物活性

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生物活性

9β,10β-epoxy Hexahydrocannabinol is a cannabinoid receptor 1 (CB1) and CB2 receptor ligand with a binding affinity of 224 nM for CB1 and 335 nM for CB2. 9β,10β-epoxy Hexahydrocannabinol reduces locomotor activity, induces catalepsy, lowers body temperature, and produces antinociceptive effects in mice. 9β,10β-epoxy Hexahydrocannabinol can be used for the study of nervous system diseases[1].

IC50 & Target[1]

CB1

224 nM (Ki)

CB2

335 nM (Ki)

体外研究
(In Vitro)

9β,10β-epoxy Hexahydrocannabinol 可分别以 224 nM 和 335 nM 的亲和力与人类 CB1 和 CB2 受体结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9β,10β-epoxy Hexahydrocannabinol 相关抗体:
体内研究
(In Vivo)

9β,10β-epoxy Hexahydrocannabinol (5-20 mg/kg; i.p.; single dose) 在健康小鼠中发挥强效类大麻素样作用，包括运动减少、僵住、镇痛和体温降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster (male, 8 weeks old, 24-30 g)[1]
Dosage: 5, 10, 20 mg/kg
Administration: i.p.; single dose
Result: Caused significant hypolocomotion, significant catalepsy (latency increase), significant hot-plate antinociception, and a significant decrease in rectal temperature.
分子量

330.46

Formula

C21H30O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

9β,10β-epoxy Hexahydrocannabinol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9β,10β-epoxy Hexahydrocannabinol1781270-07-29β,10β-EHHC 9β,10β-epoxy HHCCannabinoid ReceptorCB2 receptormicehuman CB1Cannabis sativaCB1 receptorhuman CB2mouse tetrad assaysInhibitorinhibitorinhibit

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