2. Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection
  3. Thrombin Interleukin Related RSV
  4. Bivalirudin TFA

Bivalirudin TFA  (Synonyms: 三氟醋酸比伐卢定)

目录号: HY-15664 纯度: 99.89%
COA 产品使用指南 技术支持

Bivalirudin TFA 是水蛭素类似物和抗凝血剂，是一种直接凝血酶抑制剂。Bivalirudin TFA 通过可逆性结合凝血酶，抑制凝血酶介导的纤维蛋白原裂解、凝血因子活化及血小板激活。此外，Bivalirudin TFA 还具有一定的抗病毒、抗炎和血管内皮屏障功能保护的作用。Bivalirudin TFA 可用于血栓性疾病等研究。

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Custom Peptide Synthesis

Bivalirudin TFA

Bivalirudin TFA Chemical Structure

CAS No. : 1191386-55-6

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规格 价格 是否有货 数量
5 mg ￥375
In-stock
10 mg ￥600
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50 mg ￥1000
In-stock
100 mg ￥1200
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Bivalirudin TFA:

Bivalirudin TFA 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bivalirudin TFA, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin TFA inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin TFA also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin TFA can be used for the research of thrombotic diseases and others[1][2][3][4].

IC50 & Target[2]

IL-6

 

IL-5

 

体外研究
(In Vitro)

Bivalirudin (30 μg/mL; 10 min) TFA 在 HUVECs 中抑制了 Thrombin (HY-114164) 诱导的 S1PR2 表达增加及细胞通透性升高，并逆转了细胞骨架蛋白和 β-连环蛋白的异常分布[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bivalirudin TFA 相关抗体:

Western Blot Analysis[1]

Cell Line: HUVECs treated Thrombin (HY-114164)
Concentration: 30 μg/mL
Incubation Time: 10 min
Result: Inhibited the level of S1PR2.
体内研究
(In Vivo)

Bivalirudin (2 mg/kg; 静脉注射; 隔日一次; 2 周) TFA 在新生 C57BL/6 小鼠中具有抗呼吸道合胞病毒的活性[2]。
Bivalirudin (2 mg/kg; 静脉注射; 单剂量) TFA 在小鼠中可抑制血栓形成[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice aged 5-7 days old treated respiratory syncytial virus (RSV)[2]
Dosage: 2 mg/kg
Administration: Intravenous injection; every other day; 2 weeks
Result: Significantly reduced cellular infiltration, inflammatory cytokines (e.g., IL-5, IL-6, CXCL1), and abnormal clotting parameters (e.g., D-dimer, soluble thrombomodulin) in RSV-infected lungs.
Normalized viral copy numbers and reversed histopathological changes such as nuclear pyknosis in pneumocytes.
Animal Model: P2Y12-- and WT mice with thrombosis induced by perfusion through type III collagen- or tissue factor-coated capillary chambers, and P2Y12+- mice with mesenteric artery injury induced by 12.5% FeCl3 solution[3]
Dosage: 2 mg/kg
Administration: Intravenous injection; single dose
Result: Significantly inhibited thrombus volume in P2Y12-- mice in the type III collagen-induced thrombosis model but had no significant effect in wild-type mice.
Inhibited thrombosis in both WT and P2Y12-- mice in the tissue factor-induced thrombosis model.
Delayed the time of thrombus appearance and vessel occlusion, but could not completely prevent vessel occlusion in wild-type mice in the FeCl3-induced mesenteric artery injury model in P2Y12+- mice.
Clinical Trial
分子量

2294.34

Formula

C98H138N24O33.C2HF3O2
CAS 号
性状

固体

颜色

White to off-white

Sequence

{d-Phe}-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu
Sequence Shortening

{d-Phe}-PRPGGGGNGDFEEIPEEYL
中文名称

三氟醋酸比伐卢定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (43.59 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : ≥ 50 mg/mL (21.79 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4359 mL 2.1793 mL 4.3586 mL
5 mM 0.0872 mL 0.4359 mL 0.8717 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.89%

COA (280 KB) RP-HPLC (111 KB) 元素分析报告 (203 KB)

产品使用指南 (1538 KB)
参考文献

Bivalirudin TFA 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.4359 mL 2.1793 mL 4.3586 mL 10.8964 mL
5 mM 0.0872 mL 0.4359 mL 0.8717 mL 2.1793 mL
10 mM 0.0436 mL 0.2179 mL 0.4359 mL 1.0896 mL
15 mM 0.0291 mL 0.1453 mL 0.2906 mL 0.7264 mL
20 mM 0.0218 mL 0.1090 mL 0.2179 mL 0.5448 mL
DMSO 25 mM 0.0174 mL 0.0872 mL 0.1743 mL 0.4359 mL
30 mM 0.0145 mL 0.0726 mL 0.1453 mL 0.3632 mL
40 mM 0.0109 mL 0.0545 mL 0.1090 mL 0.2724 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bivalirudin1191386-55-6三氟醋酸比伐卢定ThrombinInterleukin RelatedRSVILRespiratory syncytial viruspeptideanticoagulantanticoagulationinvasivecardiologypercutaneouscoronaryplateletsInhibitorinhibitorinhibit

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