Cromolyn disodium (Synonyms: 色甘酸钠; Cromoglycate disodium; Cromoglicic acid disodium; FPL-670)

目录号: HY-B0320A 纯度: 99.98%: Data Sheet SDS COA 产品使用指南
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技术支持

Cromolyn (Cromoglycate) disodium 是一种口服有效的 GSK-3β 抑制剂，IC₅₀ 为 2.0 μM。Cromolyn disodium 也是一种肥大细胞稳定剂，能抑制肥大细胞释放介质、调节反射性支气管收缩和降低非特异性支气管高反应性，可用支气管哮喘的研究。此外，Cromolyn disodium 还具有抗炎、抗过敏、抗组胺、抗肿瘤和神经保护等多种活性。

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Cromolyn disodium Chemical Structure

CAS No. : 15826-37-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥440	In-stock
500 mg	￥400	In-stock
1 g	￥500	In-stock
5 g	￥800	In-stock
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50 g		询价

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Customer Review

Other Forms of Cromolyn disodium:

MCE 顾客使用本产品发表的 6 篇科研文献

IHC

: Cromolyn disodium purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160. [Abstract]; The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

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生物活性
纯度 & 产品资料
参考文献

生物活性

Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects^[1]^[2]^[3]^[4]^[5].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.986 μM Compound: 2	Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay	[PMID: 23713606]
CHO	EC₅₀	1.26 μM Compound: 2	Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay	[PMID: 23713606]
CHO	EC₅₀	4.84 μM Compound: 2	Agonist activity at mouse GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay Agonist activity at mouse GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay	[PMID: 23713606]
LAD2	IC₅₀	> 1 mM Compound: DSCG	Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay	[PMID: 23617679]
Mast cell	ED₅₀	2.55 μg/mL Compound: disodium cromoglycate	Antianaphylactic activity in rat mast cells assessed as inhibition of DNP-ovalbumin-induced histamine release after 15 mins by superfusion assay Antianaphylactic activity in rat mast cells assessed as inhibition of DNP-ovalbumin-induced histamine release after 15 mins by superfusion assay	[PMID: 82617]
Mast cell	IC₅₀	6.5 μM Compound: cromolyn sodium	Antiallergic activity in rat peritoneal mast cells assessed as inhibition of ovalbumin-induced histamine release after 15 mins Antiallergic activity in rat peritoneal mast cells assessed as inhibition of ovalbumin-induced histamine release after 15 mins	[PMID: 88523]
RBL-2H3	IC₅₀	1540 μM Compound: DSCG	Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge	[PMID: 14510616]

体外研究
(In Vitro)

Cromolyn (0-100 μM; 3-10 min) disodium 在大鼠腹腔肥大细胞中，能抑制 IgE 和抗原诱导的脱颗粒及 PGD₂ 合成^[1]。
Cromolyn (0-100 μM; 0-72 h) disodium 在 Panc-1 细胞中，可阻断 S100P 促进的细胞增殖、侵袭和 NF-κB 活性增加^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cromolyn (10 mg/kg; 静脉注射; 单剂量) disodium 在大鼠中，可通过减少伊文思蓝外渗显著抑制 IgE 依赖性 PCA 中的肥大细胞激活，并完全抑制 PSA 中抗原诱导的血浆组胺增加^[1]。
Cromolyn (5 mg/kg; 腹腔注射; 5 周) disodium 在胰腺癌小鼠模型具有抗肿瘤的活性^[2]。
Cromolyn (6.3 mg/kg; 腹腔注射; 每周 5 次; 从出生后第 60 天直至安乐死) disodium 在肌萎缩侧索硬化症模型中具有改善作用^[3]。
Cromolyn (1-3.15 mg/kg; 腹腔注射; 每周 3 次; 12 周) disodium 在阿尔兹海默症小鼠模型中具有神经保护的作用^[4]。
Cromolyn (1.43-5.72 mg/kg; 腹腔注射; 1 个月) disodium 在小鼠中具有降血糖的作用^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male CB17 scid mice aged 4 weeks old treated BxPC-3 and MPanc-96 cells^[2]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 weeks
Result:	Significantly reduced tumor burden. Reduced lung metastasis in the BxPC-3 model and both liver and lung metastases in the MPanc-96 model. Had no effect on body weight.

Animal Model:	SOD1^G93A mice^[3]
Dosage:	6.3 mg/kg
Administration:	Intraperitoneal injection; 5 times a week; from postnatal day 60 until euthanasia
Result:	Delays disease onset. Improved motor deficits in the PaGE task. Increased survival of lumbar spinal cord motor neurons, decreased denervation at the neuromuscular junction. Reduced pro-inflammatory cytokine and chemokine levels in the spinal cord and plasma. Decreased mast cell degranulation in the tibialis anterior muscle.

Animal Model:	APP^Swedish expressing Tg2576 mice^[4]
Dosage:	1 and 3.15 mg/kg
Administration:	Intraperitoneal injection; 3 times a week; 12 weeks
Result:	Reduced the levels of Aβ40 and Aβ42 in brain TBS-insoluble fractions. Increased the level of Aβ38. Promoted the phagocytosis of β-amyloid by microglia.

Animal Model:	Normal Balb/c mice, chronic type II diabetic Balb/c mice, and chronic obese Balb/c mice^[5]
Dosage:	1.43, 2.86 and 5.72 mg/kg
Administration:	Intraperitoneal injection; 1 month
Result:	Dose-dependently reducted blood glucose, body weight, and resistin levels. Increased liver glycogen, insulin, C-peptide, and adiponectin levels in mice.

Clinical Trial

分子量

512.33

Formula

C₂₃H₁₄Na₂O₁₁

CAS 号

15826-37-6

性状

固体

颜色

White to off-white

中文名称

色甘酸钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)

溶解性数据

细胞实验：

H₂O 中的溶解度 : 50 mg/mL (97.59 mM; 超声助溶)

DMSO 中的溶解度 : 25 mg/mL (48.80 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9519 mL	9.7593 mL	19.5187 mL
5 mM	0.3904 mL	1.9519 mL	3.9037 mL
10 mM	0.1952 mL	0.9759 mL	1.9519 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.88 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案二

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.88 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (97.59 mM); 澄清溶液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 99.98%

选择批次：

Data Sheet (652 KB) SDS (393 KB)

COA (285 KB) HNMR (278 KB) RP-HPLC (265 KB) MS (70 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Oka T, et al. Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice. Lab Invest. 2012 Oct;92(10):1472-82. [Content Brief]

[2]. Arumugam T, et al. Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models. J Natl Cancer Inst. 2006 Dec 20;98(24):1806-18. [Content Brief]

[3]. Granucci EJ, et al. Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis. Sci Rep. 2019 Nov 27;9(1):17728. [Content Brief]

[4]. Zhang C, et al. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis. Sci Rep. 2018 Jan 18;8(1):1144. [Content Brief]

[5]. Motawi TM, et al. Naproxen and cromolyn as new glycogen synthase kinase 3β inhibitors for amelioration of diabetes and obesity: an investigation by docking simulation and subsequent in vitro/in vivo biochemical evaluation. J Biochem Mol Toxicol. 2013 Sep;27(9):425-36. [Content Brief]

Cromolyn disodium 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.9519 mL	9.7593 mL	19.5187 mL	48.7967 mL
	5 mM	0.3904 mL	1.9519 mL	3.9037 mL	9.7593 mL
	10 mM	0.1952 mL	0.9759 mL	1.9519 mL	4.8797 mL
	15 mM	0.1301 mL	0.6506 mL	1.3012 mL	3.2531 mL
	20 mM	0.0976 mL	0.4880 mL	0.9759 mL	2.4398 mL
	25 mM	0.0781 mL	0.3904 mL	0.7807 mL	1.9519 mL
	30 mM	0.0651 mL	0.3253 mL	0.6506 mL	1.6266 mL
	40 mM	0.0488 mL	0.2440 mL	0.4880 mL	1.2199 mL
H₂O	50 mM	0.0390 mL	0.1952 mL	0.3904 mL	0.9759 mL
	60 mM	0.0325 mL	0.1627 mL	0.3253 mL	0.8133 mL
	80 mM	0.0244 mL	0.1220 mL	0.2440 mL	0.6100 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Cromolyn disodium (Synonyms: 色甘酸钠; Cromoglycate disodium; Cromoglicic acid disodium; FPL-670)

Customer Review

Other Forms of Cromolyn disodium:

MCE 顾客使用本产品发表的 6 篇科研文献