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Endoxifen E-isomer hydrochloride (Synonyms: E-Endoxifen hydrochloride)

目录号: HY-18719C 纯度: 98.20%: Data Sheet SDS COA 产品使用指南
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Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride) 是 Endoxifen 的 E-异构体，是 Endoxifen Z-isomer 原料中主要的杂质。Endoxifen E-isomer hydrochloride 具有抗雌激素作用。

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Endoxifen E-isomer hydrochloride Chemical Structure

CAS No. : 1197194-61-8

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥2345	In-stock
1 mg	￥650	In-stock
5 mg	￥2600	In-stock
10 mg	￥3800	In-stock
50 mg		询价
100 mg		询价

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Other Forms of Endoxifen E-isomer hydrochloride:

Endoxifen (Z-isomer) In-stock
Endoxifen Z-isomer hydrochloride In-stock
Endoxifen hydrochloride In-stock
Endoxifen In-stock
Endoxifen (E-isomer) In-stock

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Endoxifen E-isomer hydrochloride 相关抗体

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生物活性
纯度 & 产品资料
参考文献

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生物活性

Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects^[1]^[2].

体外研究
(In Vitro)

Endoxifen E-isomer (1-1000 nM; 12 h) inhibits PGR gene expression in E₂-induced MCF-7 cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Endoxifen E-isomer hydrochloride 相关抗体:

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分子量

409.95

Formula

C₂₅H₂₈ClNO₂

CAS 号

1197194-61-8

性状

固体

颜色

White to off-white

中文名称

E-因多昔芬盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

v id="details_storage">

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

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DMSO 中的溶解度 : ≥ 30 mg/mL (73.18 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

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浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4393 mL	12.1966 mL	24.3932 mL
5 mM	0.4879 mL	2.4393 mL	4.8786 mL
10 mM	0.2439 mL	1.2197 mL	2.4393 mL

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储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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体积 v class="after-line">

分子量 *

v style="height: 20px;"> v id="errorInfoM" style="color:red;font-size: 12px;"> v class="cpd-cal-div dis-hide"> v class="calculator-brief p-dulition" style="padding-left: 0;">

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

v class="calculator-new-box">

浓度 _(start) v class="after-line">

体积 _(start) v class="after-line">

浓度 _(final) v class="after-line">

体积 _(final) v class="after-line">

v style="height: 20px;"> v id="errorInfo" class="errortip-new" style="color:red; font-size: 12px;"> v class="ss-title solution-tit" style="font-style: normal">动物实验： v class="ss-vivo" style="padding: 6px 0 7px 0;"> v style="padding:2px 14px 0;">

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

v class="invivo-step invivo-step-new">
v class="ss-vivo-order step-tit">方案一
v class="ss-vivo-text ss-vivo-text-new">
请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.10 mM); 澄清溶液

v class="invivo-brief invivo-brief-new">
此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
v class='f12'>生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
v class="invivo-step invivo-step-new">
v class="ss-vivo-order step-tit">方案二
v class="ss-vivo-text ss-vivo-text-new">
请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.10 mM); 澄清溶液

v class="invivo-brief invivo-brief-new">
此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
v class='f12'>2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
v class="invivo-step invivo-step-new">
v class="ss-vivo-order step-tit">方案三
v class="ss-vivo-text ss-vivo-text-new">
请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.10 mM); 澄清溶液

v class="invivo-brief invivo-brief-new">
此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

v class="ss-vivo" style="padding: 6px 0 7px 0;"> v id="c-qrcode-box" style="position: relative; display: none;"> v class="qrcode-box"> v id="qrcode" data-qrcode="HY-18719C">

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动物溶解方案

v id="solCalcWrapper"> v class="a-solution-item">动物溶解方案计算器 v class="a-scheme"> v class="a-scheme-tit">请输入动物实验的基本信息： v class="calculator-form c-flex-form"> v style="display: flex"> v class="c-form-item">

给药剂量

mg/kg v class="c-form-item">

动物的平均体重

g v class="c-form-item">

每只动物的给药体积

μL v class="c-form-item">

动物数量

只 v class="c-tip">由于实验过程有损耗，建议您多配一只动物的量 v class="a-scheme a-matching"> v class="a-matching-tit">请输入您的动物体内配方组成： v class="calculator-form c-flex-form" style="align-items: center; padding-bottom: 7px;justify-content: flex-start; flex-flow: row nowrap;"> v style="position:relative;"> % DMSO + v style="position: relative;"> % v class="c-form-item" style="display: flex; align-items: center;" data-bind="if: opCount() > 2"> + v style="position: relative; margin-right: 5px;"> % Tween-80 + v style="position: relative;"> % Saline 如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。 v style="margin: 10px 0;"> 方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。 v class="a-scheme a-matching" style="padding-top: 0;"> v> v data-bind="text: lastError" class="error"> v class="btn-list"> v class="calculator-form" data-bind="if: isWorkConcVisible" style="padding: 5px 12px 0; margin-bottom: 0; box-sizing: border-box; overflow: visible;"> v class="result-tit">计算结果 v class="line"> v class="result" style="margin-top: 15px;display: flex; flex-wrap: wrap;"> 工作液所需浓度 : mg/mL v class="calculator-form" data-bind="if: isStepVisible" style="padding: 0 12px; margin-bottom: 0; margin-top: 0; box-sizing: border-box; overflow: visible;"> v class="result" style="display: flex; flex-wrap: wrap; margin-top: 10px;"> 储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

v class="result-tip" style="position: relative;" data-bind="if: storeConc() > 30.0"> 您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。 v class="tooltip-panel normal-saline-div-6" style="left: 535.453px; top: 23px; position: absolute; display: none; line-height: 24px; margin-left: -40px; padding-top: 5px; margin-top: -5px;"> v class="tooltip-arrowup"> v class="tooltip-container"> 免费服务热线：400-820-3792
E-mail：sales@hg.y866.cn/biomolecule
技术支持电话：021-58950656
技术支持邮箱：tech@hg.y866.cn/biomolecule v class="result" style="margin-top: 10px; position:relative; display: flex; flex-wrap: wrap;"> 动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。 v class="tooltip-panel normal-saline-div-5" style="left: 315.453px; top: 49.6562px; position: absolute; display: none; line-height: 24px;"> v class="tooltip-arrowup"> v class="tooltip-container"> 将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液 v data-bind="if: isWorkCornOil">连续给药周期超过半月以上，请谨慎选择该方案。 v class="result-tip lh24"> 请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

v> v class="details_batch">

纯度: 98.20%

选择批次： v class="details_info_doc"> Data Sheet (616 KB) SDS (393 KB)

COA (194 KB) HNMR (172 KB) RP-HPLC (215 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Elkins P, et, al. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9. [Content Brief]

[2]. Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35(10):1942-8. [Content Brief]

v class="details_info hide" id="pro_info_4"> v class="details_info hide" id="pro_info_5">

[1]. Elkins P, et, al. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.

[2]. Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35(10):1942-8.

v class="detail_pro_fea levelMaps"> v class="details_h2">

Endoxifen E-isomer hydrochloride 相关分类

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Cancer

v> v id="stock-solution-complete" style="margin: 0;"> v class="details_h2" style=" font-size: 14px; border-bottom: 0;" class="solution-table">

完整储备液配制表

v class="ss-table"> v id="stock-solution-tips" class="ss-table-tip">

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4393 mL	12.1966 mL	24.3932 mL	60.9830 mL
	5 mM	0.4879 mL	2.4393 mL	4.8786 mL	12.1966 mL
	10 mM	0.2439 mL	1.2197 mL	2.4393 mL	6.0983 mL
	15 mM	0.1626 mL	0.8131 mL	1.6262 mL	4.0655 mL
	20 mM	0.1220 mL	0.6098 mL	1.2197 mL	3.0492 mL
	25 mM	0.0976 mL	0.4879 mL	0.9757 mL	2.4393 mL
	30 mM	0.0813 mL	0.4066 mL	0.8131 mL	2.0328 mL
	40 mM	0.0610 mL	0.3049 mL	0.6098 mL	1.5246 mL
	50 mM	0.0488 mL	0.2439 mL	0.4879 mL	1.2197 mL
	60 mM	0.0407 mL	0.2033 mL	0.4066 mL	1.0164 mL

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