2. Metabolic Enzyme/Protease Anti-infection
  3. Aminoacyl-tRNA Synthetase Bacterial
  4. Leu-AMS

Leu-AMS (compound 6)，亮氨酸类似物，是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂，IC50 值为 22.34 nM，Leu-AMS 抑制了LRS 的催化活性，但不影响亮氨酸诱导的 mTORC1 活化。Leu-AMS在癌细胞和正常细胞中显示出细胞毒性，并抑制细菌的生长。

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Leu-AMS

Leu-AMS Chemical Structure

CAS No. : 288591-93-5

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规格 价格 是否有货 数量
1 mg ￥1900
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5 mg ￥5900
询价
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Other Forms of Leu-AMS:

Leu-AMS 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria[1].

IC50 & Target

IC50: 22.34 nM (LRS)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.59 μM
Compound: 6
Cytotoxicity in human A549 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human A549 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
HCT-116 IC50
0.24 μM
Compound: 6
Cytotoxicity in human HCT-116 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human HCT-116 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
K562 IC50
0.4 μM
Compound: 6
Cytotoxicity in human K562 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human K562 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
MDA-MB-231 IC50
0.73 μM
Compound: 6
Cytotoxicity in human MDA-MB-231 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human MDA-MB-231 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
MRC5 IC50
5.9 μM
Compound: 6
Cytotoxicity in human MRC5 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human MRC5 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
SK-HEP1 IC50
0.54 μM
Compound: 6
Cytotoxicity in human SK-HEP1 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human SK-HEP1 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
SNU-638 IC50
0.84 μM
Compound: 6
Cytotoxicity in human SNU-638 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human SNU-638 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
体外研究
(In Vitro)

Leu-AMS 被证明是亮氨酰-tRNA 合成酶 (LRS) 的有效抑制剂，IC50 值为 22.34 nM。Leu-AMS 在癌细胞和正常细胞中均具有高度细胞毒性。Leu-AMS 根本不影响 S6 激酶 (S6K) 磷酸化。Leu-AMS 抑制 LRS 的催化活性，但不影响亮氨酸诱导的 mTORC1 激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Leu-AMS 相关抗体:
分子量

459.48

Formula

C16H25N7O7S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Leu-AMS 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leu-AMS288591-93-5Aminoacyl-tRNA SynthetaseBacterialtRNA Synthetase, aaRSInhibitorinhibitorinhibit

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目录号：
HY-108900
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