Quinone Reductase (醌还原酶)

Quinones, a class of organic compounds, are formally derived from aromatic compounds and are a subset of the quinoid family which also contains the quinone imines and the quinone methides. NQO1 (QR1, EC 1.6.99.2), also referred to as DT-diaphorase (formerly), nicotinamide quinone oxidoreductase 1, quinone reductase type 1, or menadione reductase, is a cytosolic flavoenzyme. Another member of the quinone oxidoreductases family is NQO2 (QR2, EC 1.10.99.2) which is also a FAD bound protein (25 kDa) and closely related to NQO1. In addition to NQO1 and NQO2 found in humans, an ancient NQO3 subfamily exists in eubacteria, NQO4 subfamily in fungi, and NQO5 subfamily in archaebacteria^[1][2].