2. Immunology/Inflammation
  3. Transmembrane Glycoprotein Toll-like Receptor (TLR)
  4. ABB071

ABB071 是一种人源化抗 CD180 单克隆抗体。ABB071 能够下调系统性红斑狼疮中高表达的 TLR7 和 IRF5 基因，并诱导 PNPT1 和 DNASE1L3 基因的表达。ABB071 可以抑制 I 型干扰素通路相关基因以及干扰素刺激基因 (ISGs) 的表达。ABB071 具有抗炎活性，能够降低炎症细胞因子的水平。ABB071 可用于系统性红斑狼疮和银屑病的研究。

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ABB071

ABB071 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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ABB071 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABB071 is a humanized anti-CD180 monoclonal antibody. ABB071 can down-regulate the highly expressed TLR7 and IRF5 genes in systemic lupus erythematosus and induce the expression of PNPT1 and DNASE1L3 genes. ABB071 can inhibit the expression of genes related to the type I interferon pathway as well as interferon-stimulated genes (ISGs). ABB071 has anti-inflammatory activity and can reduce the levels of inflammatory cytokines. ABB071 can be used for research on systemic lupus erythematosus and psoriasis[1].

IC50 & Target[1].

TLR7

 

体内研究
(In Vivo)

ABB071 在 Imiquimod (HY-B0180) 诱导的银屑病小鼠模型中，可降低银屑病面积与严重程度指数评分，并减少皮肤中关键炎症细胞因子的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABB071 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABB071ABB 071ABB-071Transmembrane GlycoproteinToll-like Receptor (TLR)Inhibitorinhibitorinhibit

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产品名称：
ABB071
目录号：
HY-P991956
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