2. Anti-infection
  3. Bacterial
  4. PACE4 Inhibitory peptide C23

PACE4 Inhibitory peptide C23  (Synonyms: Ac-(DLeu)LLLRVK-Amba)

目录号: HY-P10816
产品使用指南 技术支持

PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba))，一种有效的拟肽抑制剂，是一种 PACE4 抑制剂。PACE4 Inhibitory peptide C23 对 PCa 细胞系有抗增殖作用 (Ki = 5 nM；对 DU145 和 LNCaP 的 IC50 值分别为 25 μM 和 40 μM)。PACE4 Inhibitory peptide C23 在 LNCaP 异种移植小鼠体内也能抑制肿瘤生长。

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Custom Peptide Synthesis

PACE4 Inhibitory peptide C23

PACE4 Inhibitory peptide C23 Chemical Structure

CAS No. : 1426656-94-1

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PACE4 Inhibitory peptide C23 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (Ki = 5 nM; IC50 = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
25 μM
Compound: 2
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
[PMID: 30501188]
DU-145 IC50
25 μM
Compound: 2; C23
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
[PMID: 30180568]
DU-145 IC50
25 μM
Compound: 80
Antiproliferative activity against human DU145 cells assessed as reduction in metabolic activity after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells assessed as reduction in metabolic activity after 72 hrs by MTT assay
[PMID: 28287731]
LNCaP IC50
40 μM
Compound: 2
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
[PMID: 30501188]
LNCaP IC50
40 μM
Compound: 80
Antiproliferative activity against human LNCAP cells assessed as reduction in metabolic activity after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells assessed as reduction in metabolic activity after 72 hrs by MTT assay
[PMID: 28287731]
LNCaP IC50
45 μM
Compound: 2; C23
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
[PMID: 30180568]
分子量

1027.35

Formula

C51H90N14O8
CAS 号
Sequence

Ac-{d-Leu}-Leu-Leu-Leu-Arg-Val-Lys-Amba
Sequence Shortening

Ac-(d-Leu)LLLRVK-Amba
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PACE4 Inhibitory peptide C23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PACE4 Inhibitory peptide C231426656-94-1Ac-(DLeu)LLLRVK-AmbaBacterialPACE4antiproliferative effectsPCa cell linesInhibitorinhibitorinhibit

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