2. Neuronal Signaling Immunology/Inflammation
  3. Cholinesterase (ChE) SOD
  4. AChE/BChE-IN-34

AChE/BChE-IN-34 是一种乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 抑制剂，其 IC50 分别为 5.97 μM 和 4.57 μM。AChE/BChE-IN-34 具有抗氧化、抑制氧化应激的功能，可降低海马组织中的丙二醛 (MDA) 水平，并提高超氧化物歧化酶 (SOD) 和过氧化氢酶的水平。AChE/BChE-IN-34 可作为认知功能增强剂，在 Scopolamine (HY-N0296) 诱导的动物模型中改善学习和记忆能力。AChE/BChE-IN-34 在特定浓度范围内对神经母细胞瘤细胞无毒性。AChE/BChE-IN-34 可用于阿尔茨海默病的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AChE/BChE-IN-34

AChE/BChE-IN-34 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AChE/BChE-IN-34 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BChE-IN-34 is an acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with IC50s of 5.97 μM and 4.57 μM, respectively. AChE/BChE-IN-34 functions as an antioxidant, oxidative stress inhibitor, reduces MDA levels, and elevates SOD and catalase in hippocampal tissue. AChE/BChE-IN-34 acts as a cognitive function enhancer, improves learning and memory in a Scopolamine (HY-N0296)-induced animal model. AChE/BChE-IN-34 is non-toxic in neuroblastoma cells across a specified concentration range. AChE/BChE-IN-34 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

AChE

5.97 μM (IC50)

BChE

4.57 μM (IC50)

体外研究
(In Vitro)

AChE/BChE-IN-34 (compound 4A36) (15.625-250 μg/mL；作用 24 h) 在 15.625 至 250 μg/mL 的浓度范围内对 SH-SY5Y 神经母细胞瘤细胞无毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BChE-IN-34 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 15.625-250 μg/mL
Incubation Time: 24 h
Result: Maintained cell viability in a dose-dependent manner, with 100% viability at 15.625 μg/mL, 97.10% viability at 31.25 μg/mL, 93.21% viability at 125 μg/mL, and 62.5% viability at 250 μg/mL. Indicated no significant cytotoxicity across the tested range.
体内研究
(In Vivo)

AChE/BChE-IN-34 (compound 4A36) (3-30 mg/kg；腹腔注射；每日给药；连续 14 天) 可有效缓解 Scopolamine (HY-N0296) 诱导的大鼠认知障碍，减轻氧化应激并保护海马神经元完整性，其中 30 mg/kg 剂量下的疗效最为显著[1]。
AChE/BChE-IN-34 在动物模型中进行的急性口服毒性评价中，给药剂量高达 175 mg/kg 体重时未显示出不良反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar Albino (male/female, 200-250 g, Scopolamine-induced dementia model)[1]
Dosage: 3, 10, 30 mg/kg
Administration: i.p.; daily; 14 days
Result: Reduced escape latency and increased time in target quadrant (30 mg/kg, Morris Water Maze); reduced hippocampal AChE activity (30 mg/kg); decreased MDA levels and elevated SOD, Catalase activities (30 mg/kg); preserved hippocampal granular layer integrity with minimal vacuolation (30 mg/kg); showed partial improvements in cognitive function, oxidative stress markers, and histopathology at 3 and 10 mg/kg.
分子量

450.43

Formula

C18H14N10O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BChE-IN-34 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-34Cholinesterase (ChE)SODSuperoxide Dismutasecatalasedentate gyrussuperoxide dismutaseAlzheimer's diseaseSH-SY5Y neuroblastoma cellsmalondialdehydeacetylcholinesterasebutyrylcholinesterasehippocampal tissuescopolamine-induced animal modelInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AChE/BChE-IN-34
目录号：
HY-181167
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z